# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA995821 | Binding | Inhibition of GST-tagged SHP2 at 100 uM | 5 | ALA1140228 | single protein format | Scientific Literature | ||
2. | ALA995822 | Binding | Inhibition of GST-tagged SHP2 | 9 | ALA1140228 | single protein format | Scientific Literature | ||
3. | ALA995827 | Binding | Inhibition of EGF-induced SHP2 activation in mouse embryonic fibroblasts by immunocomplex phosphatase assay | Mus musculus | 2 | ALA1140228 | single protein format | Scientific Literature | |
4. | ALA995828 | Binding | Inhibition of EGF-induced SHP2 D61G mutant activation in mouse embryonic fibroblasts by immunocomplex phosphatase assay | Mus musculus | 2 | ALA1140228 | assay format | Scientific Literature | |
5. | ALA995829 | Binding | Inhibition of SHP2 assessed as blockade of IL3-induced ERK1/ERK2 activation in mouse Ba/F3 cells by immunoblotting | Mus musculus | 2 | ALA1140228 | cell-based format | Scientific Literature | |
6. | ALA995830 | Functional | Antiproliferative activity against IL3-stimulated mouse BA/F3 cells assessed as decrease in cell growth after 72 hrs by MTS assay | Mus musculus | 1 | ALA1140228 | cell-based format | Scientific Literature | |
7. | ALA995831 | Binding | Binding affinity to SHP2 PTP domain assessed as quenching of enzyme fluorescence by fluorescence titration assay | 6 | ALA1140228 | single protein format | Scientific Literature |