| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1022222 | B | Inhibition of acid ceramidase in human MCF7 cell lysate at 50 uM by scintillation counting | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA1022223 | B | Inhibition of acid ceramidase in human MCF7 cells at 10 uM after 2 hrs by scintillation counting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA1022225 | F | Decrease in endogenous sphingosine level in human MCF7 cells at 10 uM after 2 hrs by LC/MS analysis relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA1022226 | F | Increase in endogenous C14-ceramide level in human MCF7 cells at 10 uM after 2 hrs by LC/MS analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA1021141 | F | Increase in endogenous C16-ceramide level in human MCF7 cells at 10 uM after 2 hrs by LC/MS analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 6. | ALA1021147 | F | Induction of apoptosis in human MCF7 cells assessed as increase in caspase 3/7 activity at 10 uM after 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA1021148 | F | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA1021150 | F | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA1021151 | F | Induction of lysosomal destabilization in human MCF7 cells assessed as reduction in stability at 10 uM after 1 hr by FACS | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA1021152 | F | Induction of lysosomal destabilization in human MCF7 cells assessed as reduction in stability at 10 uM after 5 hrs by FACS | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA1021153 | F | Effect on proteolytic degradation of acid ceramidase in human MCF7 cells at 10 uM by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA1021154 | F | Effect on proteolytic degradation of acid ceramidase in human MCF7 cells up to 50 uM by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA1021155 | F | Induction of apoptosis in human MCF7 cells assessed as increase in caspase 3/7 activity after 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA2339247 | F | Elevation of total ceramide level in human MDA-MB-231 cells at 50 uM after 24 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 15. | ALA2339250 | B | Inhibition of human recombinant acid ceramidase using Acyl-NBD-C12-cer as substrate at 80 uM after 8 hrs by fluorescence assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 16. | ALA2339251 | B | Inhibition of human recombinant neutral ceramidase using Acyl-NBD-C12-cer as substrate at 80 uM after 2 hrs by fluorescence assay | Homo sapiens | 9 | single protein format | Scientific Literature |
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