# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3790663 | Functional | In vivo inhibition of CETP in human whole plasma at 120 mg for 14 days | Homo sapiens | 1 | ALA3784930 | organism-based format | Scientific Literature | |
2. | ALA1104193 | Binding | Inhibition of human plasma CETP assessed as [3H]cholesterol ester transfer after 18 hrs by scintillation proximity assay | Homo sapiens | 5 | ALA1154929 | cell-free format | Scientific Literature | |
3. | ALA1104194 | Binding | Inhibition of CETP assessed as cholesterol ester transfer after 4 hrs by microemulsion based fluorescence assay | 32 | ALA1154929 | single protein format | Scientific Literature | ||
4. | ALA1104195 | Binding | Inhibition of human plasma CETP assessed as cholesterol ester transfer after 24 hrs by fluorescence assay | Homo sapiens | 6 | ALA1154929 | cell-free format | Scientific Literature | |
5. | ALA1953400 | Binding | Inhibition of CETP-mediated BODIPY-labeled cholesteryl ester transfer after 45 mins by FRET analysis | 8 | ALA1949640 | single protein format | Scientific Literature | ||
6. | ALA1015039 | Binding | Inhibition of PLTP activity assessed as phosphatidylcholine transferred from [3H]phosphatidylcholine (dipalmitoyl)-labeled liposomes to HDL by cell based liquid scintillation counter | 2 | ALA1152778 | microsome format | Scientific Literature | ||
7. | ALA1015040 | Binding | Inhibition of LCAT activity in human plasma assessed as change in cholesteryl ester/free cholesterol ratio by cell based assay | Homo sapiens | 2 | ALA1152778 | cell-free format | Scientific Literature | |
8. | ALA1015041 | Binding | Inhibition of hepatic lipase activity assessed as release of free fatty acid from hydrolysis of VLDL by cell based assay | 2 | ALA1152778 | cell-based format | Scientific Literature | ||
9. | ALA1015042 | Binding | Inhibition of lipoprotein lipase activity assessed as release of free fatty acid from hydrolysis of VLDL by cell based assay | 2 | ALA1152778 | cell-based format | Scientific Literature | ||
10. | ALA1015043 | Binding | Inhibition of microsomal triglyceride transfer protein by cell based assay | 2 | ALA1152778 | cell-based format | Scientific Literature | ||
11. | ALA1015044 | Binding | Inhibition of endothelial lipase by cell based assay | 2 | ALA1152778 | cell-based format | Scientific Literature | ||
12. | ALA1015056 | Functional | Increase in HDLC level in high-fat fed hamster model at 30 mg/kg, po for 5 days measured after 2 hrs of last dose | Cricetinae | 2 | ALA1152778 | organism-based format | Scientific Literature | |
13. | ALA1015061 | Functional | Increase in HDLC level in normal chow diet-fed human CETP transgenic mouse model at 30 mg/kg, po for 5 days measured after 2 hrs of last dose | Mus musculus | 2 | ALA1152778 | organism-based format | Scientific Literature | |
14. | ALA1015063 | Functional | Increase in HDLC level in normal chow diet-fed cynomolgus monkey at 3 mg/kg, po for 5 days measured after 10 hrs of last dose | Macaca fascicularis | 2 | ALA1152778 | organism-based format | Scientific Literature | |
15. | ALA1015064 | Functional | Increase in HDLC level in normal chow diet-fed cynomolgus monkey at 10 mg/kg, po for 5 days measured after 10 hrs of last dose | Macaca fascicularis | 2 | ALA1152778 | organism-based format | Scientific Literature | |
16. | ALA1015065 | Functional | Increase in HDLC level in normal chow diet-fed cynomolgus monkey at 30 mg/kg, po for 5 days measured after 10 hrs of last dose | Macaca fascicularis | 2 | ALA1152778 | organism-based format | Scientific Literature | |
17. | ALA1015067 | Functional | Ex vivo inhibition of CETP in normal chow diet-fed cynomolgus monkey at 3 mg/kg, po for 5 days by Roar assay | Macaca fascicularis | 2 | ALA1152778 | organism-based format | Scientific Literature | |
18. | ALA1015068 | Functional | Ex vivo inhibition of CETP in normal chow diet-fed cynomolgus monkey at 10 mg/kg, po for 5 days by Roar assay | Macaca fascicularis | 2 | ALA1152778 | organism-based format | Scientific Literature | |
19. | ALA1015069 | Functional | Ex vivo inhibition of CETP in normal chow diet-fed cynomolgus monkey at 30 mg/kg, po for 5 days by Roar assay | Macaca fascicularis | 2 | ALA1152778 | organism-based format | Scientific Literature | |
20. | ALA1015934 | ADME | Plasma concentration in normal chow diet-fed cynomolgus monkey at 3 mg/kg, po for 5 days | Macaca fascicularis | 2 | ALA1152778 | organism-based format | Scientific Literature |