# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1031572 | Functional | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 5 days by microplate alamar blue assay | Mycobacterium tuberculosis | 37 | ALA1152738 | organism-based format | Scientific Literature | |
2. | ALA2344480 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1 by [3H] hypoxanthine uptake inhibition assay | 15 | ALA2331487 | cell-based format | Scientific Literature | ||
3. | ALA2344481 | Functional | Antimycobacterial activity Mycobacterium tuberculosis H37Rv assessed as growth inhibition measured at day 7 by broth microdilution method | Mycobacterium tuberculosis | 21 | ALA2331487 | organism-based format | Scientific Literature | |
4. | ALA2344482 | ADME | Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis | Rattus norvegicus | 18 | ALA2331487 | cell-based format | Scientific Literature | |
5. | ALA2344483 | Functional | Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of [3H] hypoxanthine uptake by liquid scintillation counting | Plasmodium falciparum | 19 | ALA2331487 | organism-based format | Scientific Literature | |
6. | ALA2410396 | ADME | Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay | Rattus norvegicus | 25 | ALA2407058 | cell-based format | Scientific Literature | |
7. | ALA2410397 | Functional | Antiplasmodial activity against erythrocytic stage of multidrug-resistant Plasmodium falciparum Thailand K1 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay | Plasmodium falciparum | 25 | ALA2407058 | organism-based format | Scientific Literature | |
8. | ALA2410398 | Functional | Antiplasmodial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum IndoChina W2 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay | Plasmodium falciparum | 25 | ALA2407058 | organism-based format | Scientific Literature | |
9. | ALA3999655 | Binding | Inhibition of recombinant Trypanosoma cruzi cruzain at 100 uM using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method relative to control | Trypanosoma cruzi | 31 | ALA3997824 | single protein format | Scientific Literature | |
10. | ALA3999656 | Binding | Inhibition of recombinant Trypanosoma brucei rhodesain at 100 uM using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method relative to control | Trypanosoma brucei | 31 | ALA3997824 | assay format | Scientific Literature | |
11. | ALA3999657 | Binding | Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method | Trypanosoma cruzi | 6 | ALA3997824 | single protein format | Scientific Literature | |
12. | ALA3999658 | Binding | Inhibition of recombinant Trypanosoma brucei rhodesain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method | Trypanosoma brucei | 6 | ALA3997824 | assay format | Scientific Literature | |
13. | ALA3999660 | Binding | Inhibition of recombinant human cathepsin S at 100 uM using cbz-val-val-arg-7-amino-4-methylcoumarin as substrate measured for 15 mins by fluorescence assay relative to control | Homo sapiens | 3 | ALA3997824 | single protein format | Scientific Literature | |
14. | ALA3999662 | Binding | Inhibition of recombinant human cathepsin S at 100 uM using cbz-val-val-arg-7-amino-4-methylcoumarin as substrate preincubated for 5 mins followed by substrate addition measured for 15 mins by fluorescence assay relative to control | Homo sapiens | 3 | ALA3997824 | single protein format | Scientific Literature | |
15. | ALA3999664 | Binding | Inhibition of rat cathepsin B at 100 uM using cbz-phe-Arg-amidomethylcoumarin as substrate measured for 15 mins by fluorescence assay relative to control | Rattus norvegicus | 3 | ALA3997824 | single protein format | Scientific Literature | |
16. | ALA3999666 | Binding | Inhibition of rat cathepsin B at 100 uM using cbz-phe-Arg-amidomethylcoumarin as substrate preincubated for 5 mins followed by substrate addition measured for 15 mins by fluorescence assay relative to control | Rattus norvegicus | 3 | ALA3997824 | single protein format | Scientific Literature | |
17. | ALA3999673 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen trypomastigote forms infected in mouse L929 cells up to 250 uM after 96 hrs by chlorophenol red-beta-D-galactopyranoside dye based assay | Trypanosoma cruzi | 21 | ALA3997824 | cell-based format | Scientific Literature | |
18. | ALA5244925 | Binding | Inhibition of Trypanosoma cruzi Cruzain | Trypanosoma cruzi | 23 | ALA5244221 | single protein format | Scientific Literature | |
19. | ALA5244931 | Binding | Inhibition of Trypanosoma brucei rhodesiense rhodesain | Trypanosoma brucei rhodesiense | 12 | ALA5244221 | single protein format | Scientific Literature | |
20. | ALA5244937 | Functional | Antitrypanosomal activity against Trypanosoma cruzi assessed as reduction in parasite growth | Trypanosoma cruzi | 29 | ALA5244221 | organism-based format | Scientific Literature |