# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA986820 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 10 | ALA1138474 | cell-based format | Scientific Literature | |
2. | ALA988582 | Binding | Activation of mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | ALA1138474 | cell-based format | Scientific Literature | |
3. | ALA988583 | Binding | Activation of mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | ALA1138474 | cell-based format | Scientific Literature | |
4. | ALA988584 | Binding | Activation of mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | Mus musculus | 3 | ALA1138474 | cell-based format | Scientific Literature | |
5. | ALA988585 | Functional | Effect on intracellular calcium level in non transfected HEK293 cells | Homo sapiens | 1 | ALA1138474 | cell-based format | Scientific Literature | |
6. | ALA988587 | Functional | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration at 1 uM in presence of TRP antagonist ruthenium red | Mus musculus | 1 | ALA1138474 | cell-based format | Scientific Literature | |
7. | ALA988594 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current density at 500 nM at a holding potential of 100 mV by whole cell patch-clamp assay in presence of calcium | Mus musculus | 2 | ALA1138474 | cell-based format | Scientific Literature | |
8. | ALA988595 | Binding | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as outward-inward rectifying current density at 500 nM at a holding potential of 100 mV by whole cell patch-clamp assay in absence of calcium | Mus musculus | 2 | ALA1138474 | cell-based format | Scientific Literature |