# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3819806 | Binding | Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents at 20 uM relative to control | Homo sapiens | 2 | ALA3817738 | cell-based format | Scientific Literature | |
2. | ALA3819807 | Binding | Activation of TREK1 (unknown origin) expressed in bAZF cells assessed as increase in current density at 10 uM relative to control | Homo sapiens | 1 | ALA3817738 | cell-based format | Scientific Literature | |
3. | ALA3819808 | Binding | Activation of TREK1 (unknown origin) expressed in bAZF cells assessed as increase in current density at 20 uM relative to control | Homo sapiens | 1 | ALA3817738 | cell-based format | Scientific Literature | |
4. | ALA3819809 | Binding | Activation of TREK1 (unknown origin) expressed in HEK293 cells assessed as increase in current density at 100 uM relative to control | Homo sapiens | 8 | ALA3817738 | cell-based format | Scientific Literature | |
5. | ALA3819810 | Binding | Activation of human TREK1 expressed in CHO cells assessed as increase in channel currents at 10 uM at +50 mV relative to control | Homo sapiens | 3 | ALA3817738 | cell-based format | Scientific Literature | |
6. | ALA615141 | Binding | Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytes | 10 | ALA1125679 | cell-based format | Scientific Literature | ||
7. | ALA615252 | Binding | Inhibitory activity against 12-lipoxygenase in rat platelet rich plasma | 10 | ALA1125679 | cell-free format | Scientific Literature | ||
8. | ALA619229 | Binding | Inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes | 10 | ALA1125679 | cell-based format | Scientific Literature | ||
9. | ALA3420871 | Binding | Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using PGH2 substrate by RP-HPLC method | Homo sapiens | 50 | ALA3414543 | cell-based format | Scientific Literature | |
10. | ALA3420872 | Binding | Inhibition of 15-LOX-1 in human blood PMNL assessed as remaining activity by measuring 15-HETE synthesis at 10 uM | Homo sapiens | 50 | ALA3414543 | single protein format | Scientific Literature | |
11. | ALA3420874 | Binding | Inhibition of 12-LOX in human blood PMNL assessed as remaining activity by measuring 12-HETE synthesis at 10 uM | Homo sapiens | 50 | ALA3414543 | single protein format | Scientific Literature | |
12. | ALA3132218 | Toxicity | Toxicity in CD-1 mouse assessed as adverse events at 2.5 to 10 mg/kg, sc | Mus musculus | 1 | ALA3124774 | organism-based format | Scientific Literature | |
13. | ALA3132219 | Toxicity | Toxicity in CD-1 mouse assessed as sedation at 2.5 to 10 mg/kg, sc | Mus musculus | 1 | ALA3124774 | organism-based format | Scientific Literature | |
14. | ALA3132220 | Functional | Antinociceptive activity in sc dosed CD-1 mouse assessed as inhibition of acetic acid-induced writhing administered 15 mins before acetic acid challenge measured after 20 mins | Mus musculus | 1 | ALA3124774 | organism-based format | Scientific Literature | |
15. | ALA3132221 | Functional | Antinociceptive activity in CD-1 mouse assessed as inhibition of acetic acid-induced writhing at 10 mg/kg, sc administered 15 mins before acetic acid challenge measured after 20 mins | Mus musculus | 26 | ALA3124774 | organism-based format | Scientific Literature | |
16. | ALA3132223 | Binding | Activation of TREK1 channel (unknown origin) expressed in Xenopus oocytes assessed as ratio of current in presence of compound to current in absence of compound at 20 uM incubated for 15 mins by two-microelectrode voltage-clamp technique | Homo sapiens | 22 | ALA3124774 | cell-based format | Scientific Literature | |
17. | ALA3270701 | Binding | Inhibition of 12-LO-mediated 12-H(P)ETE production in human polymorphonuclear leukocytes assessed as remaining activity preincubated at 10 uM for 15 mins by HPLC analysis | Homo sapiens | 14 | ALA3259515 | cell-based format | Scientific Literature | |
18. | ALA3270702 | Binding | Inhibition of 15-LO-mediated 15-H(P)ETE production in human polymorphonuclear leukocytes assessed as remaining activity preincubated at 10 uM for 15 mins by HPLC analysis | Homo sapiens | 14 | ALA3259515 | cell-based format | Scientific Literature | |
19. | ALA3993349 | Binding | Agonist activity at human TREK1 expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 29 | ALA3992520 | cell-based format | Scientific Literature | |
20. | ALA3993351 | Binding | Agonist activity at human TREK1 expressed in xenopus oocytes assessed as increase in K+ current at 20 uM measured at 0 mV by double microelectrode method relative to control | Homo sapiens | 23 | ALA3992520 | cell-based format | Scientific Literature |