GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
GSK_TCMDC: Inhibition Frequency Index (IFI). The number of non-kinase HTS assays where a compound showed > 50 % inhibition, expressed as a percentage of the number of such assays in which the compound was tested
Inhibition of Wnt3A-stimulated Wnt/beta-catenin pathway in HEK293 cells transfected with p8xTOPFlash, Renilla luciferase plasmid pRL-TK and pLKO.1 after 6 hrs by Dual topflash luciferase reporter assay
Inhibition of Wnt/beta-catenin signaling pathway in human HCT116 cells cytosol lysate harboring beta-catenin mutation assessed as reduction in Axin2 protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human HCT116 cells cytosol lysate harboring beta-catenin mutation assessed as reduction in beta-catenin protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human HCT116 whole cell lysate harboring beta-catenin mutation assessed as reduction in c-Myc protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human HCT116 whole cell lysate harboring beta-catenin mutation assessed as reduction in cyclin D1 protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human HCT116 whole cell lysate harboring beta-catenin mutation assessed as reduction in survivin protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human SW480 cells cytosol lysate harboring APC mutation assessed as reduction in Axin2 protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human SW480 cells cytosol lysate harboring APC mutation assessed as reduction in beta-catenin protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human SW480 whole cell lysate harboring APC mutation assessed as reduction in c-Myc protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human SW480 whole cell lysate harboring APC mutation assessed as reduction in cyclin D1 protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human SW480 whole cell lysate harboring APC mutation assessed as reduction in survivin protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human CRC240 cells cytosol lysate assessed as reduction in Axin2 protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human CRC240 cells cytosol lysate assessed as reduction in beta-catenin protein expression at 5 uM after 18 hrs by Western blot analysis
Inhibition of Wnt/beta-catenin signaling pathway in human CRC240 whole cell lysate assessed as reduction in c-Myc protein expression at 5 uM after 18 hrs by Western blot analysis