| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1054500 | F | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | Plasmodium falciparum | 13,467 | ALA1157539 | organism-based format | GSK Malaria Screening | |
| 2. | ALA1054501 | F | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | Plasmodium falciparum | 13,467 | ALA1157539 | organism-based format | GSK Malaria Screening | |
| 3. | ALA1054502 | F | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | Plasmodium falciparum | 13,467 | ALA1157539 | organism-based format | GSK Malaria Screening | |
| 4. | ALA1054503 | F | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | Plasmodium falciparum | 13,467 | ALA1157539 | organism-based format | GSK Malaria Screening | |
| 5. | ALA1054504 | F | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | Homo sapiens | 13,467 | ALA1157539 | cell-based format | GSK Malaria Screening | |
| 6. | ALA1054505 | F | GSK_TCMDC: Inhibition Frequency Index (IFI). The number of non-kinase HTS assays where a compound showed > 50 % inhibition, expressed as a percentage of the number of such assays in which the compound was tested | 13,467 | ALA1157539 | assay format | GSK Malaria Screening | ||
| 7. | ALA3222920 | B | Inhibition of Rac1-dependent lamellipodia formation in human SMC at 10 uM after 4 hrs by FITC-phalloidin staining based fluorescence microscopic analysis | Homo sapiens | 1 | ALA3217440 | single protein format | Scientific Literature | |
| 8. | ALA3222921 | B | Inhibition of Rac1-dependent cell adhesion in human SMC after 4 hrs by toluidine blue staining based microtiter plate reader analysis | Homo sapiens | 5 | ALA3217440 | single protein format | Scientific Literature | |
| 9. | ALA3222922 | B | Inhibition of GEF-mediated Rac activation in human SMC transfected with plasmid encoding VaV2 GEF assessed as intracellular Rac-GTP level at 25 uM after 4 hrs by G-LISA | Homo sapiens | 1 | ALA3217440 | cell-based format | Scientific Literature | |
| 10. | ALA3222923 | B | Inhibition of GEF-mediated Rac activation in human SMC transfected with plasmid encoding TrioN GEF assessed as intracellular Rac-GTP level at 25 uM after 4 hrs by G-LISA | Homo sapiens | 1 | ALA3217440 | cell-based format | Scientific Literature | |
| 11. | ALA3222924 | B | Inhibition of GEF-mediated Rac activation in human SMC transfected with plasmid encoding Tiam1 GEF assessed as intracellular Rac-GTP level at 25 uM after 4 hrs by G-LISA | Homo sapiens | 1 | ALA3217440 | cell-based format | Scientific Literature | |
| 12. | ALA3222925 | B | Inhibition of PDGF-BB-induced Rac activation in human SMC assessed as intracellular Rac-GTP level at 25 uM incubated for 1 hr prior to PDGF-BB stimulation for 2 mins by G-LISA | Homo sapiens | 1 | ALA3217440 | cell-based format | Scientific Literature | |
| 13. | ALA3222926 | B | Time-dependent inhibition of PDGF-BB-induced Rac activation in human SMC assessed as intracellular Rac-GTP level at 25 uM incubated prior to PDGF-BB stimulation for 2 mins by G-LISA | Homo sapiens | 1 | ALA3217440 | cell-based format | Scientific Literature | |
| 14. | ALA3222927 | B | Inhibition of PDGF-BB-induced RhoA activation in human SMC assessed as intracellular RhoA-GTP level at 25 uM incubated for 4 hrs prior to PDGF-BB stimulation for 2 mins by G-LISA | Homo sapiens | 4 | ALA3217440 | cell-based format | Scientific Literature | |
| 15. | ALA3222928 | B | Inhibition of PDGF-BB-induced Rac activation in human SMC assessed as intracellular Rac-GTP level incubated for 4 hrs prior to PDGF-BB stimulation for 2 mins by G-LISA | Homo sapiens | 5 | ALA3217440 | cell-based format | Scientific Literature | |
| 16. | ALA3222929 | B | Inhibition of PDGF-BB-induced Rac activation in human SMC assessed as intracellular Rac-GTP level at 25 uM incubated for 4 hrs prior to PDGF-BB stimulation for 2 mins by G-LISA | Homo sapiens | 12 | ALA3217440 | cell-based format | Scientific Literature | |
| 17. | ALA3436042 | F | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | Leishmania mexicana | 13,179 | ALA3433997 | assay format | St Jude Leishmania Screening | |
| 18. | ALA3436043 | F | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | Leishmania mexicana | 13,179 | ALA3433997 | assay format | St Jude Leishmania Screening | |
| 19. | ALA3436044 | F | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | Leishmania mexicana | 13,179 | ALA3433997 | assay format | St Jude Leishmania Screening | |
| 20. | ALA3998482 | B | Inhibition of full length PHGDH (unknown origin) using 3-phosphoglycerate as substrate incubated for 60 mins in presence of PSAT1, PSPH by resazurin based diaphorase coupled assay | Homo sapiens | 22 | ALA3997775 | single protein format | Scientific Literature |
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