# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA932801 | B | Inhibition of [3H]spermidine uptake at PAT in mouse L1210 cells | Mus musculus | 13 | ALA1141574 | cell-based format | Scientific Literature | |
2. | ALA932802 | F | Cytotoxicity against mouse L1210 cells after 48 hrs | Mus musculus | 13 | ALA1141574 | cell-based format | Scientific Literature | |
3. | ALA932803 | F | Cytotoxicity against mouse L1210 cells in presence of ODC inhibitor difluoromethylornithine | Mus musculus | 13 | ALA1141574 | cell-based format | Scientific Literature | |
4. | ALA932804 | F | Cytotoxicity against mouse L1210 cells after 24 hrs in presence of spermidine | Mus musculus | 12 | ALA1141574 | cell-based format | Scientific Literature | |
5. | ALA934015 | A | Cytotoxicity against PAT deficient CHO-MG cells after 48 hrs | Cricetulus griseus | 13 | ALA1141574 | cell-based format | Scientific Literature | |
6. | ALA934016 | A | Cytotoxicity against PAT active CHO cells after 48 hrs | Cricetulus griseus | 13 | ALA1141574 | cell-based format | Scientific Literature | |
7. | ALA934017 | A | Ratio of IC50 for PAT deficient CHO-MG cells to IC50 for PAT active CHO cells | Cricetulus griseus | 11 | ALA1141574 | cell-based format | Scientific Literature | |
8. | ALA1654122 | F | Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as increase of host survival time at 0.5 mg/kg, intranasally every 2 days 28 days after infection | Pneumocystis carinii | 2 | ALA1649301 | organism-based format | Scientific Literature | |
9. | ALA1654123 | A | Cytotoxicity against Sprague-Dawley rat alveolar macrophages assessed as cell viability at 2 mM after 3 hrs by trypan blue exclusion assay | Rattus norvegicus | 3 | ALA1649301 | cell-based format | Scientific Literature | |
10. | ALA1654125 | U | Ratio of IC50 for polyamine uptake in CHO-MG cells to IC50 for polyamine transporter expressed in CHO cells | 5 | ALA1649301 | cell-based format | Scientific Literature | ||
11. | ALA1654126 | B | Inhibition of polyamine transporter expressed in CHO cells | 5 | ALA1649301 | cell-based format | Scientific Literature | ||
12. | ALA1654127 | F | Inhibition of polyamine uptake in CHO-MG cells | Cricetulus griseus | 5 | ALA1649301 | cell-based format | Scientific Literature | |
13. | ALA1654132 | F | Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as reduction of inflammatory cell infiltration at 0.5 mg/kg, intranasally every 2 days 28 days after infection for 21 days | Pneumocystis carinii | 1 | ALA1649301 | organism-based format | Scientific Literature | |
14. | ALA1654133 | F | Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as effect on alveolar structure at 0.5 mg/kg, intranasally every 2 days 28 days after infection for 21 days | Pneumocystis carinii | 1 | ALA1649301 | organism-based format | Scientific Literature | |
15. | ALA1654134 | F | Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as effect on foamy exudates in alveoli at 0.5 mg/kg, intranasally every 2 days 28 days after infection for 21 days | Pneumocystis carinii | 1 | ALA1649301 | organism-based format | Scientific Literature | |
16. | ALA1654135 | F | Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as reduction of organism burden in lungs at 0.5 mg/kg, intranasally every 2 days 28 days after infection for 21 days | Pneumocystis carinii | 2 | ALA1649301 | organism-based format | Scientific Literature | |
17. | ALA1654136 | F | Antimicrobial activity against Pneumocystis carinii infected in Sprague-Dawley rat assessed as reduction of number of apoptotic alveolar macrophages at 0.5 mg/kg, intranasally every 2 days 28 days after infection for 21 days | Pneumocystis carinii | 2 | ALA1649301 | organism-based format | Scientific Literature | |
18. | ALA2406442 | F | Cytotoxicity against human MALME-3M cells assessed as cell viability at 0.01 uM after 96 hrs in presence of spermidine | Homo sapiens | 2 | ALA2401694 | cell-based format | Scientific Literature | |
19. | ALA2406443 | A | Cytotoxicity against human MALME-3 cells assessed as cell viability at 0.1 uM after 96 hrs in presence of spermidine | Homo sapiens | 1 | ALA2401694 | cell-based format | Scientific Literature | |
20. | ALA2404256 | A | Selectivity ratio of IC50 for human MALME-3 cells to IC50 for polyamine transport system-mediated compound uptake in human MALME-3M cells in presence of aminoguanidine | Homo sapiens | 8 | ALA2401694 | cell-based format | Scientific Literature |