# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA997747 | F | Activation of drug in FAP expressing human HT29 cells xenografted in mouse stroma assessed as FAP-mediated drug cleavage by measuring increase Pyro fluorescence after 24 hrs by confocal microscopy | Mus musculus | 1 | ALA1140867 | organism-based format | Scientific Literature | |
2. | ALA997748 | F | Photocytotoxicity against mouse FAP expressing HEK293 cells assessed as reduction of cell viability at 8 uM in presence of 2 J cm'-2 radiation by MTT assay | Homo sapiens | 1 | ALA1140867 | cell-based format | Scientific Literature | |
3. | ALA997749 | F | Activation of drug in mouse FAP expressing HEK293 cells xenografted in mouse assessed as FAP-mediated drug cleavage by measuring fluorescence localization at 25 nmol after 24 hrs | Mus musculus | 1 | ALA1140867 | organism-based format | Scientific Literature | |
4. | ALA997750 | F | Activation of drug in mouse FAP expressing HEK293 cells xenografted in mouse assessed as FAP-mediated drug cleavage by measuring fluorescence localization at 25 nmol after 24 hrs by Western blot | Mus musculus | 1 | ALA1140867 | organism-based format | Scientific Literature | |
5. | ALA997751 | F | Activation of drug in FAP expressing human HT29 cells xenografted in mouse assessed as FAP-mediated drug cleavage by measuring increase Pyro fluorescence after 24 hrs | Mus musculus | 1 | ALA1140867 | organism-based format | Scientific Literature | |
6. | ALA997752 | F | Activation of drug in mouse FAP expressing HEK293 cells xenografted in mouse assessed as FAP-mediated drug cleavage by measuring fluorescence localization after 8 hrs | Mus musculus | 2 | ALA1140867 | organism-based format | Scientific Literature | |
7. | ALA997753 | B | Activity of mouse FAP expressed in HEK293 cells assessed as enzyme-mediated drug cleavage after 24 hrs by confocal microscopy relative to control | Mus musculus | 1 | ALA1140867 | cell-based format | Scientific Literature | |
8. | ALA997754 | F | Activation of drug in mouse FAP expressing HEK293 cells xenografted in mouse assessed as FAP-mediated drug cleavage by measuring fluorescence localization at 25 nmol | Mus musculus | 1 | ALA1140867 | organism-based format | Scientific Literature | |
9. | ALA997755 | B | Activity of mouse FAP expressed in HEK293 cells assessed as enzyme-mediated drug activation by measuring intracellular fluorescence after 24 hrs by confocal microscopy relative to control | Mus musculus | 1 | ALA1140867 | cell-based format | Scientific Literature | |
10. | ALA997756 | B | Activity of mouse FAP expressed in HEK293 cells assessed as enzyme-mediated drug activation by measuring intracellular fluorescence after 1 hr by confocal microscopy relative to control | Mus musculus | 1 | ALA1140867 | cell-based format | Scientific Literature | |
11. | ALA997757 | B | Activity of mouse FAP expressed in HEK293 cells assessed as enzyme-mediated drug activation by measuring intracellular fluorescence after 6 hrs by confocal microscopy | Mus musculus | 2 | ALA1140867 | cell-based format | Scientific Literature | |
12. | ALA997758 | A | Stability in presence of antiplasmin cleaving enzyme assessed as drug cleavage | 1 | ALA1140867 | assay format | Scientific Literature | ||
13. | ALA997759 | B | Ratio of Kcat to Km for mouse FAP assessed as enzyme mediated drug cleavage by measuring increase in fluorescence intensity | Mus musculus | 1 | ALA1140867 | single protein format | Scientific Literature | |
14. | ALA997760 | B | Binding affinity to MMP3 assessed as enzyme mediated cleavage of compound by measuring increase in fluorescence after 16 hrs by HPLC-MS | 1 | ALA1140867 | single protein format | Scientific Literature | ||
15. | ALA997761 | B | Binding affinity to MMP7 assessed as enzyme mediated cleavage of compound by measuring increase in fluorescence after 16 hrs by HPLC-MS | 1 | ALA1140867 | single protein format | Scientific Literature | ||
16. | ALA997762 | B | Binding affinity to MMP11 assessed as enzyme mediated cleavage of compound by measuring increase in fluorescence after 16 hrs by HPLC-MS | 1 | ALA1140867 | single protein format | Scientific Literature | ||
17. | ALA997763 | B | Binding affinity to MMP10 assessed as enzyme mediated cleavage of compound by measuring increase in fluorescence after 16 hrs by HPLC-MS | 1 | ALA1140867 | single protein format | Scientific Literature | ||
18. | ALA997764 | B | Binding affinity to mouse FAP assessed as enzyme mediated drug cleavage by measuring increase in Pyro fluorescence | Mus musculus | 1 | ALA1140867 | single protein format | Scientific Literature | |
19. | ALA1002878 | B | Binding affinity to MMP12 assessed as enzyme mediated cleavage of compound by measuring increase in fluorescence after 16 hrs by HPLC-MS | 1 | ALA1140867 | single protein format | Scientific Literature | ||
20. | ALA1002879 | B | Binding affinity to MMP1 assessed as enzyme mediated cleavage of compound by measuring increase in fluorescence after 16 hrs by HPLC-MS | 1 | ALA1140867 | single protein format | Scientific Literature |