| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1031062 | B | Binding affinity to Bcl-xL by isothermal titration calorimetry assay | 10 | single protein format | Scientific Literature | |||
| 2. | ALA1031063 | B | Displacement of F-BakBH3 from Bfl-1 by fluorescence polarization assay | 10 | single protein format | Scientific Literature | |||
| 3. | ALA1031065 | B | Inhibition of Bcl-xL at 200 uM by 1D 1H NMR binding assay | 29 | single protein format | Scientific Literature | |||
| 4. | ALA1031066 | F | Cytotoxicity against human H1299 cells assessed as cell viability after 72 hrs by ATP-LITE assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 5. | ALA1031067 | F | Cytotoxicity against human H460 cells assessed as cell viability after 72 hrs by ATP-LITE assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 6. | ALA1031847 | F | Cytotoxicity against human PC3-ML cells assessed as cell viability after 72 hrs by ATP-LITE assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 7. | ALA1031848 | F | Induction of apoptosis in human RS11846 cells after 1 to 2 days by FITC-annexin V and propidium iodide assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 8. | ALA1031849 | F | Induction of apoptosis in human BP3 cells after 1 to 2 days by FITC-annexin V and propidium iodide assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 9. | ALA1031850 | B | Displacement of F-BakBH3 from Bcl-xL by fluorescence polarization assay | 10 | single protein format | Scientific Literature | |||
| 10. | ALA1031851 | B | Displacement of F-BakBH3 from Bcl-2 by fluorescence polarization assay | 10 | single protein format | Scientific Literature | |||
| 11. | ALA1031852 | B | Displacement of F-BakBH3 from Mcl-1 by fluorescence polarization assay | 10 | single protein format | Scientific Literature | |||
| 12. | ALA1031854 | A | Cytotoxicity against wild type mouse fibroblast assessed as induction of cell death at 10 uM by FITC-annexin V and propidium iodide assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 13. | ALA1031856 | P | Chemical stability after 60 days at room temperature by HPLC/LC-MS analysis | 7 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA1031858 | A | Stability in rat plasma after 1 hr at 37.5 degC | Rattus norvegicus | 9 | cell-free format | Scientific Literature | ||
| 15. | ALA1031859 | A | Stability in rat liver microsome at 4 uM after 1 hr | Rattus norvegicus | 9 | microsome format | Scientific Literature | ||
| 16. | ALA1031860 | A | Membrane permeability assessed as drug permeation at 100 uM at pH 7.2 after 8 hrs by PAMPA | 9 | assay format | Scientific Literature | |||
| 17. | ALA1031861 | F | Reduction of spleen weight in human Bcl2 expressing B6 transgenic mouse at 72 umol/kg, ip administered as single dose after 24 hrs | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 18. | ALA1031862 | F | Induction of spleen weight shrinkage in human Bcl2 expressing B6 transgenic mouse at 72 umol/kg, ip administered as single dose after 24 hrs | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 19. | ALA1031864 | T | Toxicity in human Bcl2 expressing B6 transgenic mouse administered as single dose at 72 umol/kg, ip after 24 hrs | Mus musculus | 9 | organism-based format | Scientific Literature | ||
| 20. | ALA5113857 | B | Inhibition of Bcl-xL/Bak (unknown origin) | Homo sapiens | 4 | protein format | Scientific Literature |
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