# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1106536 | Binding | Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay | 4 | ALA1157826 | single protein format | Scientific Literature | ||
2. | ALA1106537 | Binding | Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay | 4 | ALA1157826 | single protein format | Scientific Literature | ||
3. | ALA1106538 | Binding | Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assay | 3 | ALA1157826 | single protein format | Scientific Literature | ||
4. | ALA1106539 | Binding | Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assay | 3 | ALA1157826 | single protein format | Scientific Literature | ||
5. | ALA1106540 | Binding | Binding affinity to Bcl-XL by isothermal titration calorimetric assay | 3 | ALA1157826 | single protein format | Scientific Literature | ||
6. | ALA1106541 | Functional | Cytotoxicity against human PC3 cells after 3 days by ATP-LITE assay | Homo sapiens | 4 | ALA1157826 | cell-based format | Scientific Literature | |
7. | ALA1106542 | Functional | Cytotoxicity against human H460 cells after 3 days by ATP-LITE assay | Homo sapiens | 3 | ALA1157826 | cell-based format | Scientific Literature | |
8. | ALA1106543 | Functional | Induction of apoptosis in human BP3 cells after 1 to 2 days by FITC-conjugated annexin V and propidium iodide staining-based FACS analysis | Homo sapiens | 3 | ALA1157826 | cell-based format | Scientific Literature | |
9. | ALA1106549 | Functional | Induction of apoptosis in Bak/Bax double knockout MEF at 3 to 30 uM after 24 hrs by FITC-conjugated annexin V and propidium iodide staining-based FACS analysis | Mus musculus | 1 | ALA1157826 | cell-based format | Scientific Literature | |
10. | ALA1107441 | Functional | Antitumor activity against Mcl-1 overexpressing human M2182 cells xenografted in BALB/c mouse assessed as reduction of tumor size at 25 mg/kg, ip administered 9 times every 2 days | Homo sapiens | 1 | ALA1157826 | organism-based format | Scientific Literature | |
11. | ALA1109164 | Functional | Antitumor activity against Mcl-1 overexpressing human M2182 cells xenografted in BALB/c mouse assessed as reduction of tumor size at 10 mg/kg, ip administered 9 times every 2 days | Homo sapiens | 1 | ALA1157826 | organism-based format | Scientific Literature | |
12. | ALA1110091 | Functional | Antitumor activity against Mcl-1 overexpressing human M2182 cells xenografted in BALB/c mouse assessed as complete inhibition of tumor growth at 25 mg/kg, ip administered 9 times every 2 days | Homo sapiens | 1 | ALA1157826 | organism-based format | Scientific Literature | |
13. | ALA1110093 | Toxicity | Toxicity in BALB/c mouse xenografted with Mcl-1 overexpressing human M2182 cells at 10 to 25 mg/mg, ip administered 9 times every 2 days | Mus musculus | 3 | ALA1157826 | organism-based format | Scientific Literature | |
14. | ALA1031062 | Binding | Binding affinity to Bcl-xL by isothermal titration calorimetry assay | 10 | ALA1158469 | single protein format | Scientific Literature | ||
15. | ALA1031063 | Binding | Displacement of F-BakBH3 from Bfl-1 by fluorescence polarization assay | 10 | ALA1158469 | single protein format | Scientific Literature | ||
16. | ALA1031065 | Binding | Inhibition of Bcl-xL at 200 uM by 1D 1H NMR binding assay | 29 | ALA1158469 | single protein format | Scientific Literature | ||
17. | ALA1031066 | Functional | Cytotoxicity against human H1299 cells assessed as cell viability after 72 hrs by ATP-LITE assay | Homo sapiens | 29 | ALA1158469 | cell-based format | Scientific Literature | |
18. | ALA1031067 | Functional | Cytotoxicity against human H460 cells assessed as cell viability after 72 hrs by ATP-LITE assay | Homo sapiens | 29 | ALA1158469 | cell-based format | Scientific Literature | |
19. | ALA1031847 | Functional | Cytotoxicity against human PC3-ML cells assessed as cell viability after 72 hrs by ATP-LITE assay | Homo sapiens | 29 | ALA1158469 | cell-based format | Scientific Literature | |
20. | ALA1031848 | Functional | Induction of apoptosis in human RS11846 cells after 1 to 2 days by FITC-annexin V and propidium iodide assay | Homo sapiens | 29 | ALA1158469 | cell-based format | Scientific Literature |