| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2039370 | F | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 2. | ALA2039371 | F | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 3. | ALA2039375 | B | Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA2039376 | F | Agonist activity at GPR35 receptor in human HT-29 cells assessed as shift in resonant wavelength of biosensor stimulation after 10 mins by dynamic mass redistribution assay relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA2039377 | F | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 6. | ALA2039380 | F | Agonist activity at GPR35 receptor in human HT-29 cells at 4 uM after 10 mins by dynamic mass redistribution assay in the presence of SPB05142 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA1058996 | B | Inhibition of human RNase H assessed as substrate cleavage by fluorescence assay | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 8. | ALA1058997 | B | Inhibition of HIV1 recombinant reverse transcriptase p66/p51 heterodimer in presence of Mg2+ | Human immunodeficiency virus 1 | 12 | assay format | Scientific Literature | ||
| 9. | ALA3039488 | A | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | Cricetulus griseus | 1,862 | cell-based format | Scientific Literature | ||
| 10. | ALA3039491 | A | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | Cricetulus griseus | 1,878 | cell-based format | Scientific Literature | ||
| 11. | ALA3870650 | B | Inhibition of wild type recombinant Atg4B (unknown origin) expressed in Escherichia coli BL21 DE3 using N-terminal His6-tagged LC3B-PLA2 as substrate after 60 mins by NBD-C6-HPC dye-based fluorescence assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 12. | ALA3870653 | B | Inhibition of human recombinant GST-tagged Atg4B expressed in Escherichia coli at 500 uM using LC3B-GST as substrate after 6 mins by SDS-PAGE assay | Homo sapiens | 184 | assay format | Scientific Literature | ||
| 13. | ALA3870658 | B | Reversible inhibition of human recombinant GST-tagged Atg4B expressed in Escherichia coli using LC3B-GST as substrate after 6 mins by SDS-PAGE assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 14. | ALA3881373 | B | Antagonist activity at TLR1/2 in mouse RAW264.7 cells assessed as inhibition of Pam3CSK4-induced receptor activation by measuring NO production after 24 hrs | Mus musculus | 27 | cell-based format | Patent Bioactivity Data | ||
| 15. | ALA4343973 | B | Inhibition of recombinant human SHP2 expressed in Escherichia coli using 2P-IRS1 peptide as substrate at 1 uM after 1 hr by microplate reader analysis relative to control | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 16. | ALA4343974 | B | Inhibition of recombinant human SHP2 expressed in Escherichia coli using 2P-IRS1 peptide as substrate after 1 hr by microplate reader analysis | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 17. | ALA4343975 | F | Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability after 2 to 4 days by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4343976 | F | Potency index, ratio of SHP099 IC50 to compound IC50 for antiproliferative activity against human MDA-MB-468 cells after 2 to 4 days by CCK-8 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4343977 | F | Antiproliferative activity against SHP2 knockout human MDA-MB-468 cells with assessed as increase in cell viability at 100 uM after 2 to 4 days by CCK-8 assay relative to MDA-MB-468 cells expressing SHP2 | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA4343978 | F | Antiproliferative activity against human MDA-MB-468 3D spheroids assessed as reduction in cell viability after 2 to 4 days by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
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