# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1058996 | B | Inhibition of human RNase H assessed as substrate cleavage by fluorescence assay | Homo sapiens | 12 | ALA1153542 | single protein format | Scientific Literature | |
2. | ALA1058997 | B | Inhibition of HIV1 recombinant reverse transcriptase p66/p51 heterodimer in presence of Mg2+ | Human immunodeficiency virus 1 | 12 | ALA1153542 | assay format | Scientific Literature | |
3. | ALA1058998 | F | Antiviral activity against HIV infected in human MT4 cells up to 100 uM by multicycle infectivity assay | Human immunodeficiency virus | 8 | ALA1153542 | organism-based format | Scientific Literature | |
4. | ALA5163692 | B | Inhibition of human cytomegalovirus pHAR-UL89C expressed in Escherichia coli Rosette using Digoxigenin-labeled 5'-taatcgccttgcagcacatccccattcgccagctggcgtaatagcgaagaggcccgca ssDNA as substrate at 5 uM preincubated for 15 mins followed by substrate addition for 30 mins by plate reader assay relative to control | Cytomegalovirus | 57 | ALA5154836 | assay format | Scientific Literature | |
5. | ALA5163693 | B | Inhibition of human cytomegalovirus pHAR-UL89C expressed in Escherichia coli Rosette using Digoxigenin-labeled 5'-taatcgccttgcagcacatccccattcgccagctggcgtaatagcgaagaggcccgca ssDNA as substrate preincubated for 15 mins followed by substrate addition for 30 mins by plate reader assay | Cytomegalovirus | 38 | ALA5154836 | assay format | Scientific Literature | |
6. | ALA5163694 | B | Binding affinity to human cytomegalovirus pUL89 assessed as change in melting temperature at 20 uM preincubated for 15 mins by Thermal shift assay | Cytomegalovirus | 57 | ALA5154836 | single protein format | Scientific Literature | |
7. | ALA5163695 | F | Antiviral activity against human cytomegalovirus expressing ADCREGFP infected in HFF cells assessed as inhibition in viral replication by measuring GFP fluorescence incubated for 168 hrs by cell based assay | Cytomegalovirus | 10 | ALA5154836 | organism-based format | Scientific Literature | |
8. | ALA5163696 | T | Cytotoxicity against HFF cells assessed as cell viability incubated for 168 hrs by MTS-based Cell Titer assay | Homo sapiens | 10 | ALA5154836 | cell-based format | Scientific Literature | |
9. | ALA5163697 | T | Selectivity index, ratio of CC50 for cytotoxicity against HFF cells to EC50 for antiviral activity against human cytomegalovirus expressing ADCREGFP infected in HFF cells | 10 | ALA5154836 | cell-based format | Scientific Literature | ||
10. | ALA5163698 | P | Aqueous solubility of the compound in DPBS at pH 7.2 incubated for 72 hrs by LC-MS/MS analysis | 2 | ALA5154836 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA5163699 | A | Stability of compound in human plasma as half life measured upto 24 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA5154836 | cell-free format | Scientific Literature | |
12. | ALA5163700 | A | Stability of compound in CD-1 mouse plasma as half life measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5154836 | cell-free format | Scientific Literature | |
13. | ALA5163701 | A | Stability in human liver microsomes assessed as half life measured upto 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | ALA5154836 | microsome format | Scientific Literature | |
14. | ALA5163702 | A | Stability in mouse liver microsomes assessed as half life measured upto 60 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 3 | ALA5154836 | microsome format | Scientific Literature | |
15. | ALA5163703 | A | Apparent permeability coefficient of the compound incubated for 5 hrs by LC-MS/MS analysis based PAMPA method | 10 | ALA5154836 | assay format | Scientific Literature | ||
16. | ALA5163708 | A | Stability of compound in human plasma as compound remaining measured for 6 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA5154836 | cell-free format | Scientific Literature | |
17. | ALA5163709 | A | Stability of compound in CD-1 mouse plasma as compound remaining measured for 6 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5154836 | cell-free format | Scientific Literature |