# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1062746 | B | Inhibition of ALK5 expressed in CHO cells assessed as inhibition of TGF-beta-induced Smad2 phosphorylation at 1 uM | 40 | cell-based format | Scientific Literature | |||
2. | ALA1062749 | F | Cytotoxicity against human embryo lung fibrosis cells at 30 uM by MTT assay | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
3. | ALA1062750 | B | Inhibition of ALK4 expressed in baculovirus/Sf9 cells assessed as inhibition of receptor autophosphorylation at 0.1 uM after 3 hrs | 14 | cell-based format | Scientific Literature | |||
4. | ALA1062751 | B | Inhibition of ALK4 expressed in baculovirus/Sf9 cells assessed as inhibition of receptor autophosphorylation at 1 uM after 3 hrs | 14 | cell-based format | Scientific Literature | |||
5. | ALA1062752 | B | Inhibition of ALK5 expressed in baculovirus/Sf9 cells assessed as inhibition of receptor autophosphorylation at 0.1 uM after 3 hrs | 14 | cell-based format | Scientific Literature | |||
6. | ALA1062753 | B | Inhibition of ALK5 expressed in baculovirus/Sf9 cells assessed as inhibition of receptor autophosphorylation at 1 uM after 3 hrs | 14 | cell-based format | Scientific Literature | |||
7. | ALA1062754 | B | Inhibition of ALK7 expressed in baculovirus/Sf9 cells assessed as inhibition of receptor autophosphorylation at 0.1 uM after 3 hrs | 14 | cell-based format | Scientific Literature | |||
8. | ALA1056764 | B | Inhibition of ALK7 expressed in baculovirus/Sf9 cells assessed as inhibition of receptor autophosphorylation at 1 uM after 3 hrs | 14 | cell-based format | Scientific Literature | |||
9. | ALA1056765 | B | Selectivity for ALK5 over ALK4 | 2 | assay format | Scientific Literature | |||
10. | ALA1056766 | B | Selectivity for ALK5 over ALK7 | 2 | assay format | Scientific Literature | |||
11. | ALA2437532 | B | Inhibition of TGFbeta-induced downstream transcriptional activation of ALK5 (unknown origin) expressed in CHO-HIR cells assessed as intracellular translocation of EGFP-Smad2 at 1 uM after 2 hrs by luciferase assay | Homo sapiens | 15 | cell-based format | Scientific Literature |