# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA692990 | B | Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine | 7 | cell-based format | Scientific Literature | |||
2. | ALA746259 | B | Binding affinity towards cloned human muscarinic acetylcholine receptor M1 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | cell-based format | Scientific Literature | |||
3. | ALA752412 | B | Binding affinity towards cloned human muscarinic acetylcholine receptor M3 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | cell-based format | Scientific Literature | |||
4. | ALA746456 | B | Binding affinity towards cloned human muscarinic acetylcholine receptor M4 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | cell-based format | Scientific Literature | |||
5. | ALA748270 | B | Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | cell-based format | Scientific Literature | |||
6. | ALA744475 | B | Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | cell-based format | Scientific Literature | |||
7. | ALA1815396 | B | Selectivity for histamine H1 receptor over histamine H2 receptor in human conjuctival mast cells | Homo sapiens | 1 | assay format | Scientific Literature | ||
8. | ALA1051819 | B | Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
9. | ALA1051820 | B | Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation counting | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
10. | ALA1051823 | B | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 Flp-In cells at 10 uM by liquid scintillation counting | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
11. | ALA1051824 | B | Inhibition of human ERG expressed in HEK293 cells by patch-clamp technique | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
12. | ALA1051825 | A | Inhibition of recombinant CYP2D6 in presence of NADPH generating system | 8 | single protein format | Scientific Literature | |||
13. | ALA1051826 | A | Systemic clearance in human liver microsomes at 1 uM after 60 mins by LC-MS-MS analysis in presence of NADPH generating system | Homo sapiens | 8 | microsome format | Scientific Literature | ||
14. | ALA1051829 | A | Inhibition of recombinant CYP3A4 in presence of NADPH generating system | 1 | single protein format | Scientific Literature | |||
15. | ALA1051831 | B | Displacement of [3H]R-alpha-methylhistamine from human histamine H3 receptor expressed in CHO Flp-In cells by liquid scintillation counting | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
16. | ALA1051832 | F | Increase in NREM sleep in CD IGS rat model of insomnia at 60 mg/kg, po after 4 hrs by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
17. | ALA1051834 | F | Effect on sleep-awake pattern in CD IGS rat model of insomnia assessed as latency to 1 min NREM sleep at 60 mg/kg, po by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
18. | ALA1051836 | F | Increase in REM sleep in CD IGS rat model of insomnia at 60 mg/kg, po after 4 hrs by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
19. | ALA1051838 | F | Effect on sleep-awake pattern in CD IGS rat model of insomnia assessed as latency to 20 secs REM sleep at 60 mg/kg, po by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
20. | ALA1051840 | A | Plasma concentration in rat at 30 mg/kg, po after 1 hr | Rattus norvegicus | 3 | organism-based format | Scientific Literature |