| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA692990 | Binding | Compound was evaluated for binding affinity towards cloned human histamine H1 receptors stably expressed in CHO-K1 cells using [3H]mepyramine | 7 | ALA1136812 | cell-based format | Scientific Literature | ||
| 2. | ALA1815396 | Binding | Selectivity for histamine H1 receptor over histamine H2 receptor in human conjuctival mast cells | Homo sapiens | 1 | ALA1811812 | assay format | Scientific Literature | |
| 3. | ALA1051819 | Binding | Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation counting | Homo sapiens | 8 | ALA1153519 | cell-based format | Scientific Literature | |
| 4. | ALA1051820 | Binding | Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation counting | Homo sapiens | 6 | ALA1153519 | cell-based format | Scientific Literature | |
| 5. | ALA1051823 | Binding | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 Flp-In cells at 10 uM by liquid scintillation counting | Homo sapiens | 4 | ALA1153519 | cell-based format | Scientific Literature | |
| 6. | ALA1051824 | Binding | Inhibition of human ERG expressed in HEK293 cells by patch-clamp technique | Homo sapiens | 8 | ALA1153519 | cell-based format | Scientific Literature | |
| 7. | ALA1051825 | ADME | Inhibition of recombinant CYP2D6 in presence of NADPH generating system | 8 | ALA1153519 | single protein format | Scientific Literature | ||
| 8. | ALA1051826 | ADME | Systemic clearance in human liver microsomes at 1 uM after 60 mins by LC-MS-MS analysis in presence of NADPH generating system | Homo sapiens | 8 | ALA1153519 | microsome format | Scientific Literature | |
| 9. | ALA1051829 | ADME | Inhibition of recombinant CYP3A4 in presence of NADPH generating system | 1 | ALA1153519 | single protein format | Scientific Literature | ||
| 10. | ALA1051831 | Binding | Displacement of [3H]R-alpha-methylhistamine from human histamine H3 receptor expressed in CHO Flp-In cells by liquid scintillation counting | Homo sapiens | 8 | ALA1153519 | cell-based format | Scientific Literature | |
| 11. | ALA1051832 | Functional | Increase in NREM sleep in CD IGS rat model of insomnia at 60 mg/kg, po after 4 hrs by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | ALA1153519 | organism-based format | Scientific Literature | |
| 12. | ALA1051834 | Functional | Effect on sleep-awake pattern in CD IGS rat model of insomnia assessed as latency to 1 min NREM sleep at 60 mg/kg, po by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | ALA1153519 | organism-based format | Scientific Literature | |
| 13. | ALA1051836 | Functional | Increase in REM sleep in CD IGS rat model of insomnia at 60 mg/kg, po after 4 hrs by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | ALA1153519 | organism-based format | Scientific Literature | |
| 14. | ALA1051838 | Functional | Effect on sleep-awake pattern in CD IGS rat model of insomnia assessed as latency to 20 secs REM sleep at 60 mg/kg, po by EEG/EMG study relative to vehicle control | Rattus norvegicus | 3 | ALA1153519 | organism-based format | Scientific Literature | |
| 15. | ALA1051840 | ADME | Plasma concentration in rat at 30 mg/kg, po after 1 hr | Rattus norvegicus | 3 | ALA1153519 | organism-based format | Scientific Literature | |
| 16. | ALA1051842 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM after 60 mins by LC-MS-MS analysis in presence of NADPH generating system | Rattus norvegicus | 5 | ALA1153519 | microsome format | Scientific Literature | |
| 17. | ALA746259 | Binding | Binding affinity towards cloned human muscarinic acetylcholine receptor M1 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | ALA1136812 | cell-based format | Scientific Literature | ||
| 18. | ALA752412 | Binding | Binding affinity towards cloned human muscarinic acetylcholine receptor M3 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | ALA1136812 | cell-based format | Scientific Literature | ||
| 19. | ALA746456 | Binding | Binding affinity towards cloned human muscarinic acetylcholine receptor M4 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | ALA1136812 | cell-based format | Scientific Literature | ||
| 20. | ALA748270 | Binding | Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine | 34 | ALA1136812 | cell-based format | Scientific Literature |
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