| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1044821 | B | Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrate | Candida albicans | 82 | assay format | Scientific Literature | ||
| 2. | ALA1044822 | B | Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrate | Homo sapiens | 36 | single protein format | Scientific Literature | ||
| 3. | ALA1044823 | B | Selectivity index, ratio of IC50 for human DHFR to IC50 for Candida albicans DHFR | 36 | assay format | Scientific Literature | |||
| 4. | ALA1044824 | F | Antifungal activity against Candida albicans by alamar blue assay | Candida albicans | 35 | organism-based format | Scientific Literature | ||
| 5. | ALA1044825 | A | Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 6. | ALA2340162 | B | Binding affinity to Candida glabrata DHFR at 1 mM incubated for 2 hrs by crystallographic analysis in presence of 1 mM NADPH | Nakaseomyces glabratus | 4 | assay format | Scientific Literature | ||
| 7. | ALA2340614 | B | Binding affinity to Candida albicans DHFR at 1 mM incubated for 2 hrs by crystallographic analysis in presence of 1 mM NADPH | Candida albicans | 3 | single protein format | Scientific Literature | ||
| 8. | ALA2340615 | B | Selectivity ratio of IC50 for human DHFR to Candida glabrata DHFR | 11 | assay format | Scientific Literature | |||
| 9. | ALA2340616 | B | Inhibition of human DHFR | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 10. | ALA2340617 | B | Selectivity ratio of IC50 for human DHFR to Candida albicans DHFR | 11 | assay format | Scientific Literature | |||
| 11. | ALA2340618 | B | Inhibition of Candida glabrata DHFR | Nakaseomyces glabratus | 11 | assay format | Scientific Literature | ||
| 12. | ALA2340619 | F | Antifungal activity against Candida albicans | Candida albicans | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA2340620 | B | Inhibition of Candida albicans DHFR | Candida albicans | 11 | single protein format | Scientific Literature | ||
| 14. | ALA2340621 | F | Antifungal activity against Candida glabrata | Nakaseomyces glabratus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3227822 | B | Inhibition of Candida albicans DHFR | Candida albicans | 3 | single protein format | Scientific Literature | ||
| 16. | ALA3227823 | B | Inhibition of Candida glabrata DHFR | Nakaseomyces glabratus | 3 | assay format | Scientific Literature | ||
| 17. | ALA3226050 | F | Antifungal activity against Candida albicans | Candida albicans | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA3226051 | F | Antifungal activity against Candida glabrata | Nakaseomyces glabratus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA3226053 | B | Ratio of TMP IC50 to compound IC50 for Candida glabrata DHFR | Nakaseomyces glabratus | 1 | assay format | Scientific Literature | ||
| 20. | ALA3705794 | B | Enzyme Inhibition Assay: Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureus and S. pyogenes inhibition, and evaluated for mammalian cell toxicity. | Staphylococcus aureus | 15 | single protein format | BindingDB Database |
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