| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1037787 | B | Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenate by binding titration assay | Rattus norvegicus | 16 | tissue-based format | Scientific Literature | ||
| 2. | ALA1037788 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 3 uM after 10 mins by HPLC/UV/MS analysis | Homo sapiens | 16 | microsome format | Scientific Literature | ||
| 3. | ALA1037789 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 3 uM after 10 mins by HPLC/UV/MS analysis | Rattus norvegicus | 16 | microsome format | Scientific Literature | ||
| 4. | ALA1037790 | A | Clearance in Sprague-Dawley rat at 2 mg/kg, iv after 0.17 to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 5. | ALA1037791 | A | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv after 0.17 to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 6. | ALA1037792 | A | Half life in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 7. | ALA1043140 | A | AUC in Sprague-Dawley rat at 10 mg/kg, po dosed as aqueous suspension of 1% polysorbate 80 in 0.5% methylcellulose after 0.25 to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 8. | ALA1043141 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po dosed as aqueous suspension of 1% polysorbate 80 in 0.5% methylcellulose after 2 to 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA1043142 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg dosed as aqueous suspension of 1% polysorbate 80 in 0.5% methylcellulose after 0.25 to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA1043143 | A | AUC in Sprague-Dawley rat at 10 mg/kg, po dosed as aqueous suspension of Labrafil M 1944CS/DMAC/polysorbate 80, 85:10:5 (v/v) after 0.25 to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 11. | ALA1043144 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po dosed as aqueous suspension of Labrafil M 1944CS/DMAC/polysorbate 80, 85:10:5 (v/v) after 2 to 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 12. | ALA1043145 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg dosed as aqueous suspension of Labrafil M 1944CS/DMAC/polysorbate 80, 85:10:5 (v/v) after 0.25 to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 13. | ALA1043152 | A | Metabolic stability in NADPH-fortified human liver microsomes assessed as parent compound remaining at 10 uM after 30 mins by HPLC/UV/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 14. | ALA1043153 | A | Metabolic stability in NADPH-fortified human liver microsomes assessed as pyrazinone oxidation metabolite formation at 10 uM after 30 mins by HPLC/UV/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 15. | ALA1043154 | A | Metabolic stability in NADPH-fortified human liver microsomes assessed as GSH adduct formation at 10 uM after 30 mins by HPLC/UV/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 16. | ALA1043155 | A | Metabolic stability in NADPH-fortified rat liver microsomes assessed as parent compound remaining at 10 uM after 30 mins by HPLC/UV/MS analysis | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 17. | ALA1043156 | A | Metabolic stability in NADPH-fortified rat liver microsomes assessed as pyrazinone oxidation metabolite formation at 10 uM after 30 mins by HPLC/UV/MS analysis | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 18. | ALA1043157 | A | Metabolic stability in NADPH-fortified rat liver microsomes assessed as GSH adduct formation at 10 uM after 30 mins by HPLC/UV/MS analysis | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 19. | ALA1043158 | A | Fraction unbound in human serum after 3 to 7 hrs by equilibrium dialysis | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
| 20. | ALA1106905 | B | Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma counting | Rattus norvegicus | 26 | tissue-based format | Scientific Literature |
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