| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4340286 | F | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by dilution antimicrobial susceptibility test | Escherichia coli | 6 | organism-based format | Scientific Literature | ||
| 2. | ALA4385300 | B | Induction of read through activity at cricket paralysis virus-internal ribosome entry site premature termination codon UGA assessed as increase in octapeptide formation from FKVRQ-tRNAGln measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S]-Met-tRNA by co-sedimentation assay | Cricket paralysis virus | 15 | assay format | Scientific Literature | ||
| 3. | ALA4385301 | B | Induction of read through activity at cricket paralysis virus-internal ribosome entry site premature termination codon UGA assessed as ratio of plateau octapeptide to FKVRQ-tRNAGln measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S]-Met-tRNA by co-sedimentation assay | Cricket paralysis virus | 17 | assay format | Scientific Literature | ||
| 4. | ALA4385302 | A | Induction of read through activity at cricket paralysis virus-internal ribosome entry site codon UGG assessed as increase in octapeptide formation from FKVRQ-tRNAGln at EC50 to 2 times EC50 measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S]-Met-tRNA by co-sedimentation assay | Cricket paralysis virus | 17 | assay format | Scientific Literature | ||
| 5. | ALA4385305 | B | Induction of read through activity at cricket paralysis virus-internal ribosome entry site codon UGG assessed as rate constant for octapeptide formation from FKVRQ-tRNAGln at 5 uM preincubated for 30 secs in presence of Typ-tRNA followed by Leu-tRNA and [35S]-Met-tRNA addition by co-sedimentation assay | Cricket paralysis virus | 1 | assay format | Scientific Literature | ||
| 6. | ALA4385308 | B | Induction of read through activity at cricket paralysis virus-internal ribosome entry site premature termination codon UGA assessed as eEF2-induced 80S-Stop-IRES-PRE6 formation from 80S-Stop-IRES-POST5 at 1 to 10 uM by FRET assay | Cricket paralysis virus | 1 | assay format | Scientific Literature | ||
| 7. | ALA4385309 | A | Induction of read through activity at cricket paralysis virus-internal ribosome entry site codon UGG assessed as eEF2-induced 80S-Trp-IRES-PRE6 formation from 80S-Trp-IRES-POST5 by FRET assay | Cricket paralysis virus | 1 | assay format | Scientific Literature | ||
| 8. | ALA5216864 | B | Induction of read through activity at T-p53 R213X mutant premature termination codon in human HDQ-P1 cells assessed as increase in production of full length p53 protein by MSD assay | Homo sapiens | 90 | cell-based format | Scientific Literature | ||
| 9. | ALA5252374 | T | Cytotoxicity against Golden hamster BHK cells assessed as lethality incubated for 48 hrs by Alamar blue based colorimetric assay | Mesocricetus auratus | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA5252375 | T | Cytotoxicity against human HEK293FT cells assessed as lethality incubated for 48 hrs by Alamar blue based colorimetric assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 11. | ALA5252376 | F | Antibacterial activity against Escherichia coli R477-100 assessed as bacterial growth inhibition by CLSI protocol based double-microdilution method | Escherichia coli | 9 | organism-based format | Scientific Literature | ||
| 12. | ALA5252377 | F | Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as bacterial growth inhibition by CLSI protocol based double-microdilution method | Bacillus subtilis | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA5252378 | B | Inhibition of prokaryotic circular pBESTluc plasmid DNA from Escherichia coli S30 assessed as inhibition of translation activity by measuring luciferase activity incubated for 60 mins by fluorescence microplate reader analysis | Escherichia coli | 9 | nucleic acid format | Scientific Literature | ||
| 14. | ALA5252379 | B | Inhibition of eukaryotic luciferase T7 plasmid DNA (unknown origin) assessed as inhibition of protein translation activity by measuring luciferase activity incubated for 60 mins by fluorescence microplate reader analysis | Not specified | 9 | assay format | Scientific Literature | ||
| 15. | ALA5252380 | B | Selectivity ratio of IC50 for inhibition of eukaryotic luciferase T7 plasmid DNA (unknown origin) assessed as inhibition of protein translation activity to IC50 for inhibition of prokaryotic circular pBESTluc plasmid DNA from Escherichia coli S30 assessed as inhibition of protein translation activity | 9 | assay format | Scientific Literature |
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