# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1036965 | B | Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation counting | Homo sapiens | 42 | ALA1154624 | cell-based format | Scientific Literature | |
2. | ALA1036966 | B | Inhibition of LIMK2 in pig PTM cells assessed as inhibition of cofilin-phosphorylation at 10 nM by Western blot | Sus scrofa | 19 | ALA1154624 | cell-based format | Scientific Literature | |
3. | ALA1036967 | B | Inhibition of LIMK1 | 4 | ALA1154624 | single protein format | Scientific Literature | ||
4. | ALA1036968 | B | Inhibition of human ROCK1 expressed in baculovirus system | Homo sapiens | 4 | ALA1154624 | assay format | Scientific Literature | |
5. | ALA1036969 | B | Inhibition of human ROCK2 | Homo sapiens | 4 | ALA1154624 | single protein format | Scientific Literature | |
6. | ALA1036970 | B | Selectivity ratio of IC50 for human LIMK2 to IC50 for human ROCK1 | Homo sapiens | 4 | ALA1154624 | assay format | Scientific Literature | |
7. | ALA1036971 | B | Selectivity ratio of IC50 for human LIMK2 to IC50 for human ROCK2 | Homo sapiens | 4 | ALA1154624 | assay format | Scientific Literature | |
8. | ALA1036972 | F | Inhibition of dexamethasone-induced ocular hypertension in C57BL/6J Tyr c-Brd x 129S5/SvEvBrD hybrid mouse assessed as reduction of intraocular pressure at 5 ug after 1 hr administered as xanthan gum formulation | Mus musculus | 3 | ALA1154624 | organism-based format | Scientific Literature | |
9. | ALA1036973 | F | Inhibition of dexamethasone-induced ocular hypertension in C57BL/6J Tyr c-Brd x 129S5/SvEvBrD hybrid mouse assessed as reduction of intraocular pressure after 2 hrs administered as cosolvent/HPMC based formulation | Mus musculus | 1 | ALA1154624 | organism-based format | Scientific Literature | |
10. | ALA1036974 | F | Inhibition of dexamethasone-induced ocular hypertension in C57BL/6J Tyr c-Brd x 129S5/SvEvBrD hybrid mouse assessed as reduction of intraocular pressure at 3 ug after 2 hrs administered as cosolvent/HPMC based formulation | Mus musculus | 2 | ALA1154624 | organism-based format | Scientific Literature | |
11. | ALA1036975 | F | Increase in outflow facility in pig eye at 100 nM by eye-perfusion assay | Sus scrofa | 2 | ALA1154624 | tissue-based format | Scientific Literature | |
12. | ALA3377876 | P | Stability of the compound in HxPO4/MeOH assessed as decomposition measured at pH 7.2 and 60 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA3377877 | P | Stability of the compound in HxPO4/MeOH assessed as decomposition measured at pH 7.2 and 20 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3377878 | P | Stability of the compound in HxPO4/MeOH assessed as decomposition measured at pH 7.2 and 4 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA3377879 | P | Stability of the compound in HxPO4 assessed as decomposition measured at pH 7.2 and 60 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA3377880 | P | Stability of the compound in HxPO4/MeCN assessed as decomposition measured at pH 7.2 and 60 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA3377881 | P | Stability of the compound in MeOH assessed as decomposition measured at pH 5 to 7 and 60 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA3377882 | P | Stability of the compound in HxPO4/MeOH assessed as decomposition measured at pH 5 and 60 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA3377883 | P | Stability of the compound in HxPO4/MeOH assessed as decomposition measured at pH 13 and 60 degC after 24 hrs by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA3377884 | P | Stability of the compound in HxPO4/MeOH assessed as decomposition measured at pH 7.2 and 20 degC after 5 days by HPLC | 1 | ALA3352182 | small-molecule physicochemical format | Scientific Literature |