| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1037223 | A | Binding affinity to human sex hormone binding globulin after 30 mins by size-exclusion HPLC analysis | Homo sapiens | 1 | ALA1155242 | single protein format | Scientific Literature | |
| 2. | ALA1037225 | A | Binding affinity to human sex hormone binding globulin at 20 uCi after 60 mins by size-exclusion HPLC analysis | Homo sapiens | 1 | ALA1155242 | single protein format | Scientific Literature | |
| 3. | ALA1037227 | A | Binding affinity to rabbit sex hormone binding globulin at 20 uCi after 60 mins by size-exclusion HPLC analysis | Oryctolagus cuniculus | 1 | ALA1155242 | single protein format | Scientific Literature | |
| 4. | ALA1037229 | A | Binding affinity to mouse serum albumin at 20 uCi after 60 mins by size-exclusion HPLC analysis | Mus musculus | 1 | ALA1155242 | single protein format | Scientific Literature | |
| 5. | ALA1037233 | A | Stability in mouse serum assessed as intact compound remaining at 20 uCi after 40 mins by size-exclusion HPLC analysis | Mus musculus | 1 | ALA1155242 | cell-free format | Scientific Literature | |
| 6. | ALA1037244 | A | Binding affinity to rabbit sex hormone binding globulin at 20 uCi after 60 mins by reversed phase HPLC analysis | Oryctolagus cuniculus | 1 | ALA1155242 | single protein format | Scientific Literature | |
| 7. | ALA1037246 | P | Chemical stability in phosphate buffer saline by HPLC analysis | 1 | ALA1155242 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA1037254 | A | Cellular uptake in human OVCAR-3 cells expressing androgen receptor after 24 hrs | Homo sapiens | 1 | ALA1155242 | cell-based format | Scientific Literature | |
| 9. | ALA1037255 | A | Cellular uptake in human OVCAR-3 cells expressing androgen receptor at 1.75 uCi/mL | Homo sapiens | 1 | ALA1155242 | cell-based format | Scientific Literature | |
| 10. | ALA1037256 | A | Cellular uptake in human OVCAR-3 cells expressing androgen receptor assessed as ratio of [125I]UdR to thymidine incorporation in DNA at 1.75 uCi/mL after 24 hrs by gamma counting | Homo sapiens | 1 | ALA1155242 | cell-based format | Scientific Literature | |
| 11. | ALA1037257 | A | Stability in mouse serum assessed as time required for formation of [125I]UdR at 10 to 20 uCi/mL after 60 mins by gamma counting | Mus musculus | 1 | ALA1155242 | cell-free format | Scientific Literature | |
| 12. | ALA1037258 | A | Cellular uptake in nonproliferating human LNCAP cells expressing androgen receptor after 48 hrs by gamma counting in presence of 1 uM DHT relative to uptake in absence of DHT | Homo sapiens | 1 | ALA1155242 | cell-based format | Scientific Literature | |
| 13. | ALA1038062 | F | Cytotoxicity against human LNCAP cells expressing androgen receptor assessed as cell survival at 8 uCi/mL after 48 hrs | Homo sapiens | 1 | ALA1155242 | cell-based format | Scientific Literature | |
| 14. | ALA1040802 | F | Antitumor activity against human OVCAR-3 cells xenografted in athymic NCr mouse assessed as tumor burden in peritoneum at 0.25 mCi, ip administered 31 days after tumor implantation as single bolus dose measured 55 days after implantation by gamma counting in presence of SHBG (Rvb= 4.1 +/- 0.6 g) | Homo sapiens | 1 | ALA1155242 | organism-based format | Scientific Literature | |
| 15. | ALA1040803 | F | Antitumor activity against human OVCAR-3 cells xenografted in athymic NCr mouse assessed as solid tumor weight in peritoneum at 0.25 mCi, ip administered 31 days after tumor implantation as single bolus dose measured 55 days after implantation by gamma counting in presence of SHBG (Rvb= 1.9 +/- 0.8 g) | Homo sapiens | 1 | ALA1155242 | organism-based format | Scientific Literature | |
| 16. | ALA1040804 | A | Biodistribution in blood of athymic NCr mouse xenografted with human OVCAR-3 cells assessed per gram of tissue at 0.25 mCi, ip administered 31 days after tumor implantation as single bolus dose measured 55 days after implantation by gamma counting in presence of SHBG | Mus musculus | 1 | ALA1155242 | organism-based format | Scientific Literature | |
| 17. | ALA1039994 | T | Toxicity in athymic NCr mouse xenografted with human OVCAR-3 cells assessed as hemoglobin level at 0.25 mCi, ip administered 31 days after tumor implantation as single bolus dose measured 55 days after implantation by gamma counting in presence of SHBG (RVb= 11.5 +/- 1.3 g/dL) | Mus musculus | 1 | ALA1155242 | organism-based format | Scientific Literature | |
| 18. | ALA1039995 | T | Toxicity in athymic NCr mouse xenografted with human OVCAR-3 cells assessed as hematocrit level at 0.25 mCi, ip administered 31 days after tumor implantation as single bolus dose measured 55 days after implantation by gamma counting in presence of SHBG (Rvb= 51.4 +/- 1.6 %) | Mus musculus | 1 | ALA1155242 | organism-based format | Scientific Literature | |
| 19. | ALA1039996 | A | Binding affinity to human sex hormone binding globulin at 20 uCi after 60 mins by reversed phase HPLC analysis | Homo sapiens | 1 | ALA1155242 | single protein format | Scientific Literature | |
| 20. | ALA1040003 | A | Biodistribution in blood of athymic NCr mouse xenografted with human OVCAR-3 cells assessed per gram of tissue at an average 39.5 uCi/dose, ip administered 9 days after tumor implantation as six fractionated doses every 4 days measured after 2 weeks of last dose by gamma counting | Mus musculus | 1 | ALA1155242 | organism-based format | Scientific Literature |
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