| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1837501 | B | Inhibition of gamma-secretase-mediated cleavage of amyloid precursor protein in human IMR32 cells after 2 hrs using MBPC-125 substrate by ELISA assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA1837502 | B | Inhibition of gamma-secretase in human SNC-204B8 cells assessed as Amyloid beta protein 1-x level after 16 hrs by ELISA assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA1837503 | B | Inhibition of gamma-secretase-mediated notch cleavage in human SNC-204B8 cells after 16 hrs by luciferase reporter gene assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 4. | ALA1837504 | B | Selectivity ratio of IC50 for gamma-secretase-mediated Notch cleavage in human SNC-204B8 cells to IC50 for gamma-secretase-mediated amyloid precursor protein-cleavage in human IMR32 cells | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 5. | ALA1837505 | A | Oxidative metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of 1 mM NADPH | Mus musculus | 22 | microsome format | Scientific Literature | ||
| 6. | ALA1837506 | A | Oxidative metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins in presence of 1 mM NADPH | Homo sapiens | 22 | microsome format | Scientific Literature | ||
| 7. | ALA1837507 | F | Reduction of amyloid beta x-40 level in wild type FVB mouse cortex | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA1837508 | A | Oral bioavailability in wild type FVB mouse | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA1837509 | A | Clearance in wild type FVB mouse | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA1037933 | B | Inhibition of gamma secretase in human IMR32 cells assessed as inhibition of Abeta40 site cleavage by ELISA | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 11. | ALA1037934 | A | Metabolic stability in mouse liver microsomes at 1 uM after 30 mins in presence of NADPH | Mus musculus | 30 | microsome format | Scientific Literature | ||
| 12. | ALA1037935 | A | Metabolic stability in human liver microsomes at 1 uM after 30 mins in presence of NADPH | Homo sapiens | 30 | microsome format | Scientific Literature | ||
| 13. | ALA1037936 | A | Metabolic stability in human liver microsomes at 2 uM after 30 mins in presence of UDPGA | Homo sapiens | 30 | microsome format | Scientific Literature | ||
| 14. | ALA1037937 | A | Metabolic stability in mouse liver microsomes at 2 uM after 30 mins in presence of UDPGA | Mus musculus | 30 | microsome format | Scientific Literature | ||
| 15. | ALA1037938 | A | Half life in rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA1037939 | A | Clearance in rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA1037940 | A | AUC in rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA1037941 | A | Oral bioavailability in rat | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA1112565 | B | Inhibition of gamma-secretase | 30 | assay format | Scientific Literature | |||
| 20. | ALA1112566 | A | Oral bioavailability in Sprague-Dawley rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!