# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1789905 | F | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | Plasmodium yoelii | 4,416 | organism-based format | Novartis Malaria Screening | ||
2. | ALA1040691 | F | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | Plasmodium falciparum | 5,614 | organism-based format | Novartis Malaria Screening | ||
3. | ALA1040692 | F | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | Plasmodium falciparum | 5,614 | organism-based format | Novartis Malaria Screening | ||
4. | ALA1040693 | T | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | Homo sapiens | 5,614 | cell-based format | Novartis Malaria Screening | ||
5. | ALA1040694 | F | NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. | 5,614 | assay format | Novartis Malaria Screening | |||
6. | ALA4418835 | B | Inhibition of human recombinant ENTPD5 expressed in insect cells assessed as reduction in UDP hydrolysis at 1 uM incubated for 1 hr in presence of UMP, GTP and ATP by Escherichia coli UMP kinase pyrH catalyzed UMP phosphorylation coupled luciferase assay | Homo sapiens | 158 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4418836 | B | Inhibition of human recombinant ENTPD5 expressed in insect cells assessed as reduction in UDP hydrolysis up to 10 uM incubated for 1 hr in presence of UMP, GTP and ATP by Escherichia coli UMP kinase pyrH catalyzed UMP phosphorylation coupled luciferase assay | Homo sapiens | 158 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4418837 | B | Inhibition of recombinant Escherichia coli UMP kinase pyrH catalyzed UMP phosphorylation in presence of GTP and ATP incubated for 1 hr by luminescence based assay | Escherichia coli | 158 | single protein format | Patent Bioactivity Data | ||
9. | ALA4418838 | B | Inhibition of human recombinant ENTPD5 expressed in insect cells assessed as reduction in reduction in UDP hydrolysis by measuring inorganic phosphate release incubated for 1 hr by malachite green based assay | Homo sapiens | 158 | cell-based format | Patent Bioactivity Data |