| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1040691 | F | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | Plasmodium falciparum | 5,614 | organism-based format | Novartis Malaria Screening | ||
| 2. | ALA1040692 | F | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | Plasmodium falciparum | 5,614 | organism-based format | Novartis Malaria Screening | ||
| 3. | ALA1040693 | T | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | Homo sapiens | 5,614 | cell-based format | Novartis Malaria Screening | ||
| 4. | ALA1040694 | F | NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. | 5,614 | assay format | Novartis Malaria Screening | |||
| 5. | ALA1789905 | F | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | Plasmodium yoelii | 4,416 | organism-based format | Novartis Malaria Screening | ||
| 6. | ALA3214928 | F | PubChem BioAssay. MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set7. (Class of assay: confirmatory) | 61 | cell-based format | PubChem BioAssays | |||
| 7. | ALA3214989 | F | PubChem BioAssay. MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set8. (Class of assay: confirmatory) | 61 | cell-based format | PubChem BioAssays | |||
| 8. | ALA3215056 | F | PubChem BioAssay. MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set9. (Class of assay: confirmatory) | 26 | cell-based format | PubChem BioAssays | |||
| 9. | ALA3215207 | F | PubChem BioAssay. MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set8. (Class of assay: confirmatory) | 54 | cell-based format | PubChem BioAssays | |||
| 10. | ALA3215208 | F | PubChem BioAssay. qPCR Assay for MLANA Expression Measured in Cell-Based System Using RT-PCR - 2084-13_Inhibitor_Dose_DryPowder_Activity. (absACnn = the concentration at which the curve crosses threshold nn uM) (Class of assay: confirmatory) | 30 | cell-based format | PubChem BioAssays | |||
| 11. | ALA3215285 | F | PubChem BioAssay. Primary human melanocyte cytotoxicity assay Measured in Cell-Based System Using Plate Reader - 2084-06_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) | 16 | cell-based format | PubChem BioAssays | |||
| 12. | ALA3214820 | F | PubChem BioAssay. MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set9. (Class of assay: confirmatory) | 32 | cell-based format | PubChem BioAssays | |||
| 13. | ALA3214857 | F | PubChem BioAssay. qPCR Assay for DCT Expression Measured in Cell-Based System Using RT-PCR - 2084-12_Inhibitor_Dose_DryPowder_Activity. (absACnn = the concentration at which the curve crosses threshold nn uM) (Class of assay: confirmatory) | 28 | cell-based format | PubChem BioAssays | |||
| 14. | ALA3214893 | F | PubChem BioAssay. MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set6. (Class of assay: confirmatory) | 33 | cell-based format | PubChem BioAssays | |||
| 15. | ALA3214912 | F | PubChem BioAssay. MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set8. (Class of assay: confirmatory) | 34 | cell-based format | PubChem BioAssays | |||
| 16. | ALA3214916 | F | PubChem BioAssay. MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set5. (Class of assay: confirmatory) | 33 | cell-based format | PubChem BioAssays | |||
| 17. | ALA4403460 | B | Activation of rat spleen microsome HO-1 preincubated for 10 mins followed by NADPH addition and measured after 15 mins by gas chromatography relative to control | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
| 18. | ALA4403461 | B | Activation of rat brain microsome HO-2 expressed in Escherichia coli BL21 (DE3) cells preincubated for 10 mins followed by NADPH addition and measured after 15 mins by gas chromatography relative to control | Rattus norvegicus | 6 | microsome format | Scientific Literature |
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