| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1040691 | F | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | Plasmodium falciparum | 5,614 | ALA1156829 | organism-based format | Novartis Malaria Screening | |
| 2. | ALA1040692 | F | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | Plasmodium falciparum | 5,614 | ALA1156829 | organism-based format | Novartis Malaria Screening | |
| 3. | ALA1040693 | T | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | Homo sapiens | 5,614 | ALA1156829 | cell-based format | Novartis Malaria Screening | |
| 4. | ALA1040694 | F | NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. | 5,614 | ALA1156829 | assay format | Novartis Malaria Screening | ||
| 5. | ALA2422848 | B | Inhibition of C-terminal YFP-fused Escherichia coli FtsZ cloned in Escherichia coli envA1 assessed as mislocalization of protein throughout cell at 120 uM after 30 to 60 mins by fluorescence microscopic analysis | Escherichia coli | 1 | ALA2417459 | assay format | Scientific Literature | |
| 6. | ALA3429348 | B | Inhibition of bacterial FtsZ GTPase activity (unknown origin) | Not specified | 2 | ALA3425501 | assay format | Scientific Literature | |
| 7. | ALA3429349 | B | Competitive inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay in presence of 10 to 1250 uM GTP | Escherichia coli | 1 | ALA3425501 | single protein format | Scientific Literature | |
| 8. | ALA3999561 | B | Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 20 uM after 1 hr relative to control | Bacillus subtilis | 8 | ALA3997817 | assay format | Scientific Literature | |
| 9. | ALA3999562 | B | Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 100 uM after 1 hr relative to control | Bacillus subtilis | 8 | ALA3997817 | assay format | Scientific Literature | |
| 10. | ALA3999563 | B | Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 200 uM after 1 hr relative to control | Bacillus subtilis | 8 | ALA3997817 | assay format | Scientific Literature | |
| 11. | ALA3999564 | B | Inhibition of Escherichia coli N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 20 uM after 1 hr relative to control | Escherichia coli | 8 | ALA3997817 | assay format | Scientific Literature | |
| 12. | ALA3999565 | B | Inhibition of Escherichia coli N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 100 uM after 1 hr relative to control | Escherichia coli | 8 | ALA3997817 | assay format | Scientific Literature | |
| 13. | ALA3999566 | B | Inhibition of Escherichia coli N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 200 uM after 1 hr relative to control | Escherichia coli | 8 | ALA3997817 | assay format | Scientific Literature | |
| 14. | ALA4035100 | F | Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 3 days by MTT assay | Homo sapiens | 11 | ALA4033661 | cell-based format | Scientific Literature | |
| 15. | ALA4315097 | B | Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP assay | Homo sapiens | 125 | ALA4311995 | single protein format | Scientific Literature | |
| 16. | ALA4428171 | B | Inhibition of Escherichia coli FtsZ assessed as reduction in polymerization | Escherichia coli | 2 | ALA4428024 | single protein format | Scientific Literature | |
| 17. | ALA4428173 | F | Antimicrobial activity against Bacillus subtilis | Bacillus subtilis | 5 | ALA4428024 | organism-based format | Scientific Literature | |
| 18. | ALA4428175 | F | Antimicrobial activity against Escherichia coli | Escherichia coli | 4 | ALA4428024 | organism-based format | Scientific Literature | |
| 19. | ALA4428177 | F | Antimicrobial activity against methicillin resistant Staphylococcus aureus | Staphylococcus aureus | 2 | ALA4428024 | organism-based format | Scientific Literature | |
| 20. | ALA4428182 | B | Inhibition of Mycobacterium tuberculosis FtsZ assessed as reduction in GTPase activity by malachite green assay | Mycobacterium tuberculosis | 1 | ALA4428024 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!