| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1064623 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/92/BCN 83 promastigotes at 100 ug/ml after 48 hrs by resazurin method | Leishmania infantum | 33 | organism-based format | Scientific Literature | ||
| 2. | ALA1064624 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/92/BCN 83 promastigotes after 48 hrs by resazurin method | Leishmania infantum | 33 | organism-based format | Scientific Literature | ||
| 3. | ALA1064625 | A | Cytotoxicity against mouse J774 cells after 24 hrs by by resazurin reduction test | Mus musculus | 33 | cell-based format | Scientific Literature | ||
| 4. | ALA1064626 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/92/BCN 83 promastigotes-infected in BALB/c mouse assessed as reduction of parasite burden in spleen at 5 mg/kg, ip once daily for 5 days by limit dilution assay relative to control | Leishmania infantum | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA1064627 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/92/BCN 83 promastigotes-infected in BALB/c mouse assessed as reduction of parasite burden in liver at 5 mg/kg, ip once daily for 5 days by limit dilution assay relative to control | Leishmania infantum | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA1064628 | T | Toxicity in BALB/c mouse assessed as reduction in body weight at 5 mg/kg, ip once daily for 5 days | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA1064629 | T | Toxicity in BALB/c mouse assessed as reduction hair loss at 5 mg/kg, ip once daily for 5 days | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA3090669 | F | Trypanocidal activity against bloodstream trypomastigote stage of Trypanosoma cruzi Y infected in BALB/c mouse assessed as reduction of survival rate at 10 mg/kg/day, ip qd administered for 5 days measured daily until day 30 post-infection | Trypanosoma cruzi | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA3090670 | F | Trypanocidal activity against bloodstream trypomastigote stage of Trypanosoma cruzi Y infected in BALB/c mouse assessed as reduction of parasitemia at 10 mg/kg/day, ip qd administered for 5 days measured on day 10 post-infection by microscopic analysis relative to control | Trypanosoma cruzi | 4 | organism-based format | Scientific Literature | ||
| 10. | ALA3090671 | F | Trypanocidal activity against bloodstream trypomastigote stage of Trypanosoma cruzi Y infected in BALB/c mouse assessed as reduction of parasitemia at 10 mg/kg/day, ip qd administered for 3 days measured on day 8 post-infection by microscopic analysis relative to control | Trypanosoma cruzi | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA3090715 | F | Trypanocidal activity against intracellular amastigote stage of Trypanosoma cruzi CL-B5 infected in mouse NCTC-929 cells assessed as reduction of parasite load after 7 days by resazurin dye-based fluorometric analysis | Trypanosoma cruzi | 9 | organism-based format | Scientific Literature | ||
| 12. | ALA3090716 | F | Leishmanicidal activity against intracellular amastigote stage of Leishmania amazonensis MHOM/Br/79/Maria infected in mouse J774 cells assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania amazonensis | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA3090717 | F | Leishmanicidal activity against intracellular amastigote stage of Leishmania infantum MCAN/ES/96/BCN150 infected in mouse J774 cells assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania infantum | 9 | organism-based format | Scientific Literature | ||
| 14. | ALA3090722 | F | Selectivity index, ratio of CC50 for mouse NCTC-929 cells to IC50 for extracellular epimastigote stage of Trypanosoma cruzi CL-B5 | 4 | cell-based format | Scientific Literature | |||
| 15. | ALA3090723 | A | Cytotoxicity against mouse NCTC-929 cells assessed as reduction of cell viability after 24 hrs by resazurin dye-based fluorometric analysis | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 16. | ALA3090724 | A | Cytotoxicity against mouse J774 cells assessed as reduction of cell viability after 24 hrs by resazurin dye-based fluorometric analysis | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 17. | ALA3090725 | F | Trypanocidal activity against extracellular epimastigote stage of Trypanosoma cruzi CL-B5 assessed as reduction of parasite load after 72 hrs by resazurin dye-based fluorometric analysis | Trypanosoma cruzi | 28 | organism-based format | Scientific Literature | ||
| 18. | ALA3090726 | F | Leishmanicidal activity against extracellular promastigote stage of Leishmania amazonensis MHOM/Br/79/Maria assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania amazonensis | 28 | organism-based format | Scientific Literature | ||
| 19. | ALA3090727 | F | Leishmanicidal activity against extracellular promastigote stage of Leishmania guyanensis 141/93 assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania guyanensis | 28 | organism-based format | Scientific Literature | ||
| 20. | ALA3090728 | F | Leishmanicidal activity against extracellular promastigote stage of Leishmania braziliensis 2903 assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania braziliensis | 28 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!