# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1065327 | B | Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay | Homo sapiens | 45 | ALA1153247 | single protein format | Scientific Literature | |
2. | ALA1065328 | F | Cytotoxicity against human BRCA1 deficient HeLa cells after 7 days by fluorimetric analysis | Homo sapiens | 44 | ALA1153247 | cell-based format | Scientific Literature | |
3. | ALA1065329 | F | Cytotoxicity against human HeLa cells expressing BRCA1 after 7 days by fluorimetric analysis | Homo sapiens | 44 | ALA1153247 | cell-based format | Scientific Literature | |
4. | ALA1065330 | F | Selectivity ratio, CC50 for human BRCA1 deficient HeLa cells to CC50 for human HeLa cells expressing BRCA1 | Homo sapiens | 8 | ALA1153247 | cell-based format | Scientific Literature | |
5. | ALA1065333 | A | Clearance in rat | Rattus norvegicus | 7 | ALA1153247 | organism-based format | Scientific Literature | |
6. | ALA1115414 | A | Intrinsic clearance in rat lung microsomes assessed per mg of protein in presence of NADPH | Rattus norvegicus | 1 | ALA1157008 | microsome format | Scientific Literature | |
7. | ALA1115415 | B | Inhibition of human PARP1 by SPA | Homo sapiens | 30 | ALA1157008 | single protein format | Scientific Literature | |
8. | ALA1115416 | B | Inhibition of PARP in hydrogen peroxide-induced human HeLa cells assessed as inhibition DNA-damage-induced PARylation | Homo sapiens | 30 | ALA1157008 | cell-based format | Scientific Literature | |
9. | ALA1115417 | F | Antiproliferative activity against BRCA1 deficient human HeLa cells after 7 days by cell titer-blue assay | Homo sapiens | 22 | ALA1157008 | cell-based format | Scientific Literature | |
10. | ALA1115418 | F | Antiproliferative activity against human HeLa cells expressing wild type BRCA1 after 7 days by cell titer-blue assay | Homo sapiens | 22 | ALA1157008 | cell-based format | Scientific Literature | |
11. | ALA1115419 | A | Intrinsic clearance in rat liver microsomes assessed per mg of protein up to 90 mins | Rattus norvegicus | 16 | ALA1157008 | microsome format | Scientific Literature | |
12. | ALA1115420 | A | Intrinsic clearance in mouse liver microsomes assessed per mg of protein up to 90 mins | Mus musculus | 16 | ALA1157008 | microsome format | Scientific Literature | |
13. | ALA1115421 | A | Plasma clearance in rat | Rattus norvegicus | 16 | ALA1157008 | organism-based format | Scientific Literature | |
14. | ALA1115422 | A | Oral bioavailability in rat | Rattus norvegicus | 7 | ALA1157008 | organism-based format | Scientific Literature | |
15. | ALA1115426 | F | Selectivity index, ratio of CC50 for BRCA1 proficient human HeLa cells to CC50 for BRCA1 deficient human HeLa cells | Homo sapiens | 9 | ALA1157008 | cell-based format | Scientific Literature | |
16. | ALA1115427 | A | Biodistribution in iv dosed rat urine within 24 hrs | Rattus norvegicus | 1 | ALA1157008 | organism-based format | Scientific Literature | |
17. | ALA1116313 | A | Biodistribution in iv dosed rat bile within 24 hrs | Rattus norvegicus | 1 | ALA1157008 | organism-based format | Scientific Literature | |
18. | ALA1116314 | A | Biodistribution in iv dosed rat urine assessed as tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate level within 24 hrs | Rattus norvegicus | 1 | ALA1157008 | organism-based format | Scientific Literature | |
19. | ALA1116315 | A | Intrinsic clearance in rat liver microsomes assessed per mg of protein up to 60 mins in presence of rat recombinant CYP1A2 | Rattus norvegicus | 16 | ALA1157008 | microsome format | Scientific Literature | |
20. | ALA1116316 | A | Metabolic stability in rat heart microsomes assessed as compound degradation in presence of NADPH | Rattus norvegicus | 1 | ALA1157008 | microsome format | Scientific Literature |