| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1001629 | P | Chemical stability assessed as hydrolysis half life at 1.5 mg at pH 1.4 measured at 24 hrs interval for 12 days by 31P NMR analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA1001633 | A | Metabolic stability in human serum assessed as hydrolysis half life at 0.25 mM measured for 4 days by HPLC | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 3. | ALA1001637 | A | Stability at 77 ug/ml after 30 mins by HPLC in presence of calf intestine alkaline phosphatase | 3 | assay format | Scientific Literature | |||
| 4. | ALA1001638 | B | Activity of human NTPDase 1 expressed in human 293T cells assessed as drug hydrolysis at 100 uM after 20 mins relative to ATP | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA1001639 | B | Activity of human NTPDase 2 expressed in human 293T cells assessed as drug hydrolysis at 100 uM after 20 mins relative to ATP | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA1001640 | B | Activity of human NTPDase 3 expressed in human 293T cells assessed as drug hydrolysis at 100 uM after 20 mins relative to ATP | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA1002519 | B | Activity of human NTPDase 8 expressed in human 293T cells assessed as drug hydrolysis at 100 uM after 20 mins relative to ATP | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA1004221 | B | Activity of human NPP1 expressed in human 293T cells assessed as drug hydrolysis at 100 uM after 20 mins by reverse-phase HPLC relative to p-nitrophenyl-thymidine-5-monophosphate | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA1004222 | B | Activity of human NPP3 expressed in human 293T cells assessed as drug hydrolysis at 100 uM after 20 mins by reverse-phase HPLC relative to p-nitrophenyl-thymidine-5-monophosphate | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA1005024 | F | Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | Meleagris gallopavo | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA1005025 | F | Agonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration at 100 uM by dual-excitation spectrofluorimetric analysis | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA1005026 | F | Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA1005027 | F | Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA1005028 | P | Dissociation constant, pKa of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA1005029 | F | Antagonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as inhibition of 2-MeS-ADP-induced increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | Meleagris gallopavo | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA1005030 | F | Antagonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA1005031 | F | Antagonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA1005032 | F | Antagonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA1005033 | B | Inhibition of human NTPDase 1 expressed in human 293T cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA1005034 | B | Inhibition of human NTPDase 2 expressed in human 293T cells | Homo sapiens | 3 | cell-based format | Scientific Literature |
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