| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1100948 | B | Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 2. | ALA1101142 | B | Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 3. | ALA1772492 | P | Lipophilicity, log D of the compound | 10 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA1772497 | A | Apparent intrinsic clearance in human liver microsomes assessed per mg of protein | Homo sapiens | 9 | microsome format | Scientific Literature | ||
| 5. | ALA1772498 | A | Apparent intrinsic clearance in human hepatocytes assessed per million of cells | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 6. | ALA3129928 | A | Drug metabolism in Sprague-Dawley rat assessed as (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol formation at 50 mg/kg, po after 5 days by HPLC analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA3129929 | A | Drug metabolism in Sprague-Dawley rat assessed as (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol formation at 50 mg/kg, po after 5 days by HPLC analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA3129930 | A | Drug metabolism in Sprague-Dawley rat assessed as compound remaining at 50 mg/kg, po after 5 days by HPLC analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA3129937 | F | Antidiabetic activity in Beagle dog assessed as urinary glucose excretion at 0.03 mg/kg, po administered 1 hr prior to glucose challenge measured after 1 to 24 hrs relative to dapagliflozin | Canis lupus familiaris | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA3129938 | F | Antidiabetic activity in Beagle dog assessed as urinary glucose excretion at 0.03 mg/kg, po administered 1 hr prior to glucose challenge measured after 8 to 24 hrs relative to dapagliflozin | Canis lupus familiaris | 6 | organism-based format | Scientific Literature | ||
| 11. | ALA3129939 | F | Antidiabetic activity in Beagle dog assessed as urinary glucose excretion at 0.03 mg/kg, po administered 1 hr prior to glucose challenge measured after 1 to 8 hrs relative to dapagliflozin | Canis lupus familiaris | 6 | organism-based format | Scientific Literature | ||
| 12. | ALA3129940 | F | Antidiabetic activity in Sprague-Dawley rat assessed as urinary glucose excretion at 1 mg/kg, po administered 1 hr prior to glucose challenge measured after 1 to 24 hrs relative to dapagliflozin | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA3129941 | F | Antidiabetic activity in Sprague-Dawley rat assessed as urinary glucose excretion at 1 mg/kg, po administered 1 hr prior to glucose challenge measured after 4 to 24 hrs relative to dapagliflozin | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 14. | ALA3129942 | F | Antidiabetic activity in Sprague-Dawley rat assessed as urinary glucose excretion at 1 mg/kg, po administered 1 hr prior to glucose challenge measured after 1 to 4 hrs relative to dapagliflozin | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 15. | ALA3130097 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA3130098 | A | AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA3130099 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA3130100 | A | Oral bioavailability in Sprague-Dawley rat at 1 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA3130101 | A | Half life in Sprague-Dawley rat at 1 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA3130102 | A | AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature |
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