| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1072864 | B | Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system at 100 uM by scintillation counting | Homo sapiens | 18 | ALA1157722 | assay format | Scientific Literature | |
| 2. | ALA1072865 | B | Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system at 100 uM by scintillation counting | Homo sapiens | 18 | ALA1157722 | assay format | Scientific Literature | |
| 3. | ALA3134967 | B | Inhibition of DOT1L (unknown origin) using [methyl-3H]SAM and biotinylated nucleosome PRC2 and H3K27Me3 activator peptide up to 80 uM by [3H]methyl group incorporation assay | Homo sapiens | 30 | ALA3132825 | single protein format | Scientific Literature | |
| 4. | ALA3134968 | B | Inhibition of EZH2 (unknown origin) using [methyl-3H]SAM and biotinylated nucleosome PRC2 and H3K27Me3 activator peptide up to 80 uM by [3H]methyl group incorporation assay | Homo sapiens | 30 | ALA3132825 | single protein format | Scientific Literature | |
| 5. | ALA3134970 | B | Inhibition of human DNMT3A catalytic domain (623 to 912 amino acids) at 10 uM after 1 hr by fluorescence assay | Homo sapiens | 8 | ALA3132825 | single protein format | Scientific Literature | |
| 6. | ALA3134971 | B | Inhibition of human DNMT3A catalytic domain (623 to 912 amino acids) at 100 uM after 1 hr by fluorescence assay | Homo sapiens | 8 | ALA3132825 | single protein format | Scientific Literature | |
| 7. | ALA3134972 | B | Inhibition of human DNMT1 using [methyl-3H]SAM and biotinylated hemimethylated DNA duplex at 50 to 200 uM by [3H]methyl group incorporation assay | Homo sapiens | 1 | ALA3132825 | single protein format | Scientific Literature | |
| 8. | ALA3134973 | B | Inhibition of human DNMT1 using [methyl-3H]SAM and biotinylated hemimethylated DNA duplex at 100 uM by [3H]methyl group incorporation assay | Homo sapiens | 31 | ALA3132825 | single protein format | Scientific Literature | |
| 9. | ALA4034605 | F | Growth inhibition of human U937 cells at 50 uM after 72 hrs by MTT assay | Homo sapiens | 2 | ALA4033641 | cell-based format | Scientific Literature | |
| 10. | ALA4034606 | F | Growth inhibition of human K562 cells at 50 uM after 72 hrs by MTT assay | Homo sapiens | 1 | ALA4033641 | cell-based format | Scientific Literature | |
| 11. | ALA4034608 | B | Inhibition of DNMT1 (unknown origin) at 100 uM using poly(dI-dC).poly(dI-dC) as substrate preincubated for 15 mins followed by substrate/[3H]-SAM addition measured after 120 mins by liquid scintillation counting analysis | Homo sapiens | 12 | ALA4033641 | single protein format | Scientific Literature | |
| 12. | ALA4034609 | B | Inhibition of DNMT3A/3L (unknown origin) at 100 uM using biotinylated DNA oligonucleotides as substrate preincubated for 15 mins followed by substrate/[3H]-SAM addition measured after 4 hrs by liquid scintillation counting analysis | Homo sapiens | 12 | ALA4033641 | protein complex format | Scientific Literature | |
| 13. | ALA4034610 | B | Inhibition of DNMT3B/3L (unknown origin) at 100 uM using biotinylated DNA oligonucleotides as substrate preincubated for 15 mins followed by substrate/[3H]-SAM addition measured after 4 hrs by liquid scintillation counting analysis | Homo sapiens | 12 | ALA4033641 | protein complex format | Scientific Literature |
The page will load shortly, Thanks for your patience!