Antidepressant activity in Long-Evans rat assessed as effect on number of boli excreted at 20 to 90 mg/kg, sc administered 21 days measured for 6 mins by Porsalt forced-swim test relative to vehicle-treated control
Antidepressant activity in Long-Evans rat assessed as effect on inverts at 20 to 90 mg/kg, sc administered 21 days measured for 6 mins by Porsalt forced-swim test relative to vehicle-treated control
Antidepressant activity in Long-Evans rat assessed as effect on dives at 20 to 90 mg/kg, sc administered 21 days measured for 6 mins by Porsalt forced-swim test relative to vehicle-treated control
Antidepressant activity in Long-Evans rat assessed as effect on swim speed at 20 to 90 mg/kg, sc administered 21 days measured for 6 mins by Porsalt forced-swim test relative to vehicle-treated control
Antidepressant activity in Long-Evans rat assessed as mobile index at 90 mg/kg, sc administered 21 days measured for 6 mins by Porsalt forced-swim test (Rvb = 286 +/- 8.7 secs)
Antidepressant activity in Long-Evans rat assessed as mobile index at 20 mg/kg, sc administered 21 days measured for 6 mins by Porsalt forced-swim test (Rvb = 286 +/- 8.7 secs)
Toxicity in Long-Evans rat assessed as hypothalamic aromatase level at 90 mg/kg, sc measured per mg of protein measured for 21 days (Rvb = 60 +/- 6.1 pmol/hr)
Toxicity in Long-Evans rat assessed as hypothalamic aromatase level at 20 mg/kg, sc measured per mg of protein measured for 21 days (Rvb = 60 +/- 6.1 pmol/hr)