# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1068015 | Binding | Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch clamp method | 50 | ALA1156924 | cell-based format | Scientific Literature | ||
2. | ALA1068016 | Binding | Inhibition of L type calcium channel alpha-1c/alpha-2-delta-1/beta-1b expressed in HEK293 cells in presence of -100 mV holding potential by whole-cell patch clamp method | 13 | ALA1156924 | cell-based format | Scientific Literature | ||
3. | ALA1068017 | Binding | Inhibition of L-type calcium channel alpha-1c/alpha-2-delta-1/beta-1b expressed in HEK293 cells by FLIPR method | 23 | ALA1156924 | cell-based format | Scientific Literature | ||
4. | ALA1068018 | Physicochemical | Aqueous solubility at pH 7.4 | 12 | ALA1156924 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA1071406 | Functional | Analgesic activity in Sprague-Dawley rat assessed as inhibition of spinal nerve injury-induced mechanical allodynia at 30 mg/kg, po after 60-90 mins | Rattus norvegicus | 9 | ALA1156924 | organism-based format | Scientific Literature | |
6. | ALA1071407 | Functional | Analgesic activity in Sprague-Dawley rat assessed as inhibition of spinal nerve injury-induced thermal hyperalgesia at 30 mg/kg, po after 60-90 mins | Rattus norvegicus | 9 | ALA1156924 | organism-based format | Scientific Literature | |
7. | ALA1071408 | ADME | Cmax at Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
8. | ALA1071409 | ADME | AUC (0 to 24 hrs) at Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
9. | ALA1071410 | ADME | Half life at Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
10. | ALA1071411 | ADME | Cmax at Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
11. | ALA1071412 | ADME | Tmax at Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
12. | ALA1071413 | ADME | AUC (0 to 24 hrs) at Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
13. | ALA1071414 | ADME | Half life at Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
14. | ALA1071415 | ADME | Oral bioavailability at Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 3 | ALA1156924 | organism-based format | Scientific Literature | |
15. | ALA3880762 | Binding | Inhibition of human alpha1G T-type calcium channel expressed in HEK293 cells assessed as current dependent channel blocking at -110 mV holding potential with pre-pulse at -80 mV for 1 sec prior to test pulse at -40 mV for 50 ms by whole cell patch clamp assay | Homo sapiens | 3 | ALA3880396 | cell-based format | Patent Bioactivity Data |