# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1114099 | Binding | Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assay | 61 | ALA1153760 | single protein format | Scientific Literature | ||
2. | ALA1114100 | Binding | Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation counting | 61 | ALA1153760 | single protein format | Scientific Literature | ||
3. | ALA1114101 | Functional | Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by chemiluminescence assay | Homo sapiens | 61 | ALA1153760 | cell-based format | Scientific Literature | |
4. | ALA1114102 | Functional | Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine incorporation assay | Homo sapiens | 61 | ALA1153760 | cell-based format | Scientific Literature | |
5. | ALA1114103 | Functional | Agonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity at 10 uM after 3 days by chemiluminescence assay | Homo sapiens | 61 | ALA1153760 | cell-based format | Scientific Literature | |
6. | ALA1114104 | Functional | Agonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation at 10 uM after 24 hrs by [14C]thymidine incorporation assay | Homo sapiens | 61 | ALA1153760 | cell-based format | Scientific Literature | |
7. | ALA1114105 | Functional | Uterotropic activity in rat assessed as inhibition of estrone-stimulated uterine weight at 1 mg/kg, po QD after 3 days | Rattus norvegicus | 61 | ALA1153760 | organism-based format | Scientific Literature | |
8. | ALA1114106 | Functional | Uterotropic activity in rat assessed as increase in uterine weight at 1 mg/kg, po QD after 3 days | Rattus norvegicus | 43 | ALA1153760 | organism-based format | Scientific Literature |