# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1113189 | Binding | Inhibition of Sprague-Dawley rat lens aldose reductase by spectrofluorimetry | Rattus norvegicus | 19 | ALA1154220 | single protein format | Scientific Literature | |
2. | ALA1113190 | Physicochemical | Inhibition of advanced glycation end product formation after 14 day in phosphate buffer at pH7.4 by spectrofluorimetry | 19 | ALA1154220 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA1777323 | Functional | Antitrypanosomal activity against epimastigote form of Trypanosoma cruzi assessed as inhibition of parasite growth | Trypanosoma cruzi | 10 | ALA1772982 | organism-based format | Scientific Literature | |
4. | ALA1777324 | ADME | Cytotoxicity against african green monkey Vero cells assessed as cell viability after 72 hrs by FACS analysis | Chlorocebus sabaeus | 10 | ALA1772982 | cell-based format | Scientific Literature | |
5. | ALA1777325 | Toxicity | Selectivity index, ratio of IC50 for african green monkey Vero cells to IC50 for epimastigote form of Trypanosoma cruzi | 10 | ALA1772982 | cell-based format | Scientific Literature | ||
6. | ALA1777326 | Functional | Antitrypanosomal activity against metacyclic forms of Trypanosoma cruzi infected in vero cells assessed as inhibition of infection at IC25 concentration after 12 hrs | Trypanosoma cruzi | 10 | ALA1772982 | organism-based format | Scientific Literature | |
7. | ALA1777327 | Functional | Antitrypanosomal activity against metacyclic forms of Trypanosoma cruzi infected in vero cells assessed as decrease in trypomastigotes at IC25 concentration after 12 hrs | Trypanosoma cruzi | 10 | ALA1772982 | organism-based format | Scientific Literature | |
8. | ALA1777328 | Functional | Antitrypanosomal activity against blood trypomastigote forms of Trypanosoma cruzi infected in BALB/c mouse assessed as mouse survival rate at 1 mg/kg, ip administered 7 days postinfection once daily for 5 days | Trypanosoma cruzi | 10 | ALA1772982 | organism-based format | Scientific Literature | |
9. | ALA1777329 | Functional | Antitrypanosomal activity against blood trypomastigote forms of Trypanosoma cruzi infected in BALB/c mouse assessed as decrease in parasitemia at 5 mg/kg, ip administered 7 days post infection once daily for 5 days measured on day 22 post infection by microhematocrit method relative to control | Trypanosoma cruzi | 9 | ALA1772982 | organism-based format | Scientific Literature | |
10. | ALA1777330 | Functional | Antitrypanosomal activity against blood trypomastigote forms of Trypanosoma cruzi infected in BALB/c mouse assessed as decrease in parasitemia at 5 mg/kg, ip administered 7 days post infection once daily for 5 days measured after 40 days post infection by microhematocrit method relative to control | Trypanosoma cruzi | 9 | ALA1772982 | organism-based format | Scientific Literature | |
11. | ALA1777331 | Functional | Antitrypanosomal activity against blood trypomastigote forms of Trypanosoma cruzi infected in BALB/c mouse assessed as decrease in anti-parasite antibodies level at 5 mg/kg, ip administered 7 days post infection once daily for 5 days measured after 40 to 70 days post infection by ELISA relative to control | Trypanosoma cruzi | 9 | ALA1772982 | organism-based format | Scientific Literature | |
12. | ALA1777332 | Functional | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes assessed as increase in vacuolization at IC25 concentration after 72 hrs by transmission electron microscopy | Trypanosoma cruzi | 9 | ALA1772982 | organism-based format | Scientific Literature | |
13. | ALA1777333 | Functional | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes assessed as shrinkage of the protozoa at IC25 concentration after 72 hrs by transmission electron microscopy | Trypanosoma cruzi | 9 | ALA1772982 | organism-based format | Scientific Literature | |
14. | ALA1777334 | Functional | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes assessed as cytoplasmic membrane burst at IC25 concentration after 72 hrs by transmission electron microscopy | Trypanosoma cruzi | 5 | ALA1772982 | organism-based format | Scientific Literature | |
15. | ALA1777335 | Functional | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes assessed as undulating cytoplasm membrane at IC25 concentration after 72 hrs by transmission electron microscopy | Trypanosoma cruzi | 5 | ALA1772982 | organism-based format | Scientific Literature | |
16. | ALA1777336 | Functional | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes assessed as strongly electrodense cytoplasm at IC25 concentration after 72 hrs by transmission electron microscopy | Trypanosoma cruzi | 1 | ALA1772982 | organism-based format | Scientific Literature | |
17. | ALA1777337 | Functional | Antitrypanosomal activity against Trypanosoma cruzi epimastigotes assessed as very dilated cytoplasmic structures at IC25 concentration after 72 hrs by transmission electron microscopy | Trypanosoma cruzi | 1 | ALA1772982 | organism-based format | Scientific Literature | |
18. | ALA1777340 | Toxicity | Toxicity in BALB/c mouse assessed as mortality at 5 mg/kg, ip | Mus musculus | 9 | ALA1772982 | organism-based format | Scientific Literature |