# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1106145 | Binding | Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1 | Homo sapiens | 21 | ALA1156995 | cell-based format | Scientific Literature | |
2. | ALA1106146 | Functional | Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production | Homo sapiens | 15 | ALA1156995 | cell-based format | Scientific Literature | |
3. | ALA1106147 | Functional | Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum | Homo sapiens | 15 | ALA1156995 | cell-based format | Scientific Literature | |
4. | ALA1106149 | ADME | Oral bioavailability in rat at 10 mg/kg in presence of lmwitor:tween | Rattus norvegicus | 4 | ALA1156995 | organism-based format | Scientific Literature | |
5. | ALA1106152 | ADME | Half life in rat at 2 mg/kg, iv | Rattus norvegicus | 7 | ALA1156995 | organism-based format | Scientific Literature | |
6. | ALA1106154 | ADME | Clearance in rat at 10 mg/kg, po or 2 mg/kg, iv | Rattus norvegicus | 7 | ALA1156995 | organism-based format | Scientific Literature |