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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA1108920 Binding Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of glucose uptake Homo sapiens 20 ALA1156151 cell-based format Scientific Literature 2. ALA1108921 Binding Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of glucose uptake Homo sapiens 20 ALA1156151 cell-based format Scientific Literature 3. ALA1108922 Binding Selectivity ratio of IC50 for human SGLT1 to IC50 for human SGLT2 Homo sapiens 20 ALA1156151 assay format Scientific Literature 4. ALA1108923 Functional Antihyperglycemic activity in Sprague-Dawley rat assessed as inhibition of streptozotocin-induced increase in blood glucose level at 0.3 to 3 mg/kg, po Rattus norvegicus 5 ALA1156151 organism-based format Scientific Literature 5. ALA1108924 ADME Metabolic stability in human liver microsomes assessed as compound remaining at 5 umol/L after 15 mins by LC/MS/MS analysis Homo sapiens 6 ALA1156151 microsome format Scientific Literature 6. ALA1108925 ADME Metabolic stability in cryopreserved human hepatocytes assessed as compound remaining at 5 umol/L after 240 mins by LC/MS/MS analysis Homo sapiens 6 ALA1156151 cell-based format Scientific Literature 7. ALA1108928 ADME Protein binding in human serum at 1 ug/ml Homo sapiens 5 ALA1156151 cell-free format Scientific Literature 8. ALA1108929 ADME Cmax in rat at 1 mg/kg, po and 1 mg/kg, iv Rattus norvegicus 1 ALA1156151 organism-based format Scientific Literature 9. ALA1108930 ADME Tmax in rat at 1 mg/kg, po and 1 mg/kg, iv Rattus norvegicus 1 ALA1156151 organism-based format Scientific Literature 10. ALA1108931 ADME Half life in rat at 1 mg/kg, po and 1 mg/kg, iv Rattus norvegicus 1 ALA1156151 organism-based format Scientific Literature 11. ALA1108932 ADME Oral bioavailability in rat at 1 mg/kg Rattus norvegicus 1 ALA1156151 organism-based format Scientific Literature 12. ALA1108933 ADME Volume of distribution at steady state in rat at 1 mg/kg, po and 1 mg/kg, iv Rattus norvegicus 1 ALA1156151 organism-based format Scientific Literature 13. ALA1108934 ADME Clearance in rat at 1 mg/kg, po and 1 mg/kg, iv Rattus norvegicus 1 ALA1156151 organism-based format Scientific Literature 14. ALA1108935 ADME Cmax in dog at 1 mg/kg, po and 1 mg/kg, iv Canis lupus familiaris 1 ALA1156151 organism-based format Scientific Literature 15. ALA1108936 ADME Tmax in dog at 1 mg/kg, po and 1 mg/kg, iv Canis lupus familiaris 1 ALA1156151 organism-based format Scientific Literature 16. ALA1108937 ADME Half life in dog at 1 mg/kg, po and 1 mg/kg, iv Canis lupus familiaris 1 ALA1156151 organism-based format Scientific Literature 17. ALA1108938 ADME Oral bioavailability in dog at 1 mg/kg Canis lupus familiaris 1 ALA1156151 organism-based format Scientific Literature 18. ALA1108939 ADME Volume of distribution at steady state in dog at 1 mg/kg, po and 1 mg/kg, iv Canis lupus familiaris 1 ALA1156151 organism-based format Scientific Literature 19. ALA1108940 ADME Clearance in dog at 1 mg/kg, po and 1 mg/kg, iv Canis lupus familiaris 1 ALA1156151 organism-based format Scientific Literature 20. ALA1108947 ADME Drug level in rat plasma at 1 mg/kg, po after 1 hr Rattus norvegicus 1 ALA1156151 organism-based format Scientific Literature