# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1108920 | Binding | Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of glucose uptake | Homo sapiens | 20 | ALA1156151 | cell-based format | Scientific Literature | |
2. | ALA1108921 | Binding | Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of glucose uptake | Homo sapiens | 20 | ALA1156151 | cell-based format | Scientific Literature | |
3. | ALA1108922 | Binding | Selectivity ratio of IC50 for human SGLT1 to IC50 for human SGLT2 | Homo sapiens | 20 | ALA1156151 | assay format | Scientific Literature | |
4. | ALA1108923 | Functional | Antihyperglycemic activity in Sprague-Dawley rat assessed as inhibition of streptozotocin-induced increase in blood glucose level at 0.3 to 3 mg/kg, po | Rattus norvegicus | 5 | ALA1156151 | organism-based format | Scientific Literature | |
5. | ALA1108924 | ADME | Metabolic stability in human liver microsomes assessed as compound remaining at 5 umol/L after 15 mins by LC/MS/MS analysis | Homo sapiens | 6 | ALA1156151 | microsome format | Scientific Literature | |
6. | ALA1108925 | ADME | Metabolic stability in cryopreserved human hepatocytes assessed as compound remaining at 5 umol/L after 240 mins by LC/MS/MS analysis | Homo sapiens | 6 | ALA1156151 | cell-based format | Scientific Literature | |
7. | ALA1108928 | ADME | Protein binding in human serum at 1 ug/ml | Homo sapiens | 5 | ALA1156151 | cell-free format | Scientific Literature | |
8. | ALA1109857 | Functional | Antihyperglycemic activity in streptozotocin-induced Sprague-Dawley rat assessed as reduction in glucose AUC (0 to 8 hrs) at 0.3 to 3 mg/kg, po | Rattus norvegicus | 5 | ALA1156151 | organism-based format | Scientific Literature |