# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1104441 | Binding | Inhibition of squalene synthase in rat liver S10 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 1 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
2. | ALA1104442 | Functional | Inhibition of osteoclastogenesis in RANKL-stimulated mouse RAW264.7 cells assessed as mature osteoclasts containing 3 or more nuclei at 10 uM after 3 days by using TRAP staining | Mus musculus | 13 | ALA1156999 | cell-based format | Scientific Literature | |
3. | ALA1104443 | Functional | Inhibition of osteoclastogenesis in RANKL-stimulated human PBMC cells assessed as mature osteoclasts containing 3 or more nuclei at 10 uM after 5 days by using TRAP staining | Homo sapiens | 6 | ALA1156999 | cell-based format | Scientific Literature | |
4. | ALA1104444 | Binding | Inhibition of squalene synthase in rat liver microsomes assessed as conversion of [1-3H]FPP to [3H]squalene level after 60 mins by liquid scintillation counting | Rattus norvegicus | 5 | ALA1156999 | microsome format | Scientific Literature | |
5. | ALA1104445 | Binding | Inhibition of FPPS in rat liver S10 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 1 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
6. | ALA1104446 | Binding | Inhibition of FPPS in rat liver S10 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 10 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
7. | ALA1104447 | Functional | Vasodilatory activity in Wistar rat endothelium-intact thoracic aortic strip assessed as inhibition of phenylephrine-induced contraction after 120 mins | Rattus norvegicus | 7 | ALA1156999 | tissue-based format | Scientific Literature | |
8. | ALA1104448 | Functional | Vasodilatory activity in Wistar rat endothelium-intact thoracic aortic strip assessed as inhibition of phenylephrine-induced contraction after 120 mins in the presence of ODQ | Rattus norvegicus | 2 | ALA1156999 | tissue-based format | Scientific Literature | |
9. | ALA1104450 | Binding | Binding affinity to bone mineral hydroxyapatite assessed as residual concentration of compound after 6 hrs | 13 | ALA1156999 | assay format | Scientific Literature | ||
10. | ALA1104451 | Binding | Binding affinity to bone mineral hydroxyapatite assessed as residual concentration of compound after 24 hrs | 13 | ALA1156999 | assay format | Scientific Literature | ||
11. | ALA1104452 | Binding | Inhibition of squalene synthase in rat liver S10 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 10 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
12. | ALA1104453 | Binding | Inhibition of squalene synthase in rat liver S100 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 1 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
13. | ALA1104454 | Binding | Inhibition of squalene synthase in rat liver S100 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 10 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature |