# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1105365 | B | Inhibition of NF-kappaB expressed in HEK293 cells assessed as inhibition of TNF-alpha-stimulated transcriptional activation at 10 uM treated 24 hrs before TNFalpha challenge measured after 20 to 24 hrs by luciferase reporter gene assay | 37 | ALA1156197 | cell-based format | Scientific Literature | ||
2. | ALA1105366 | B | Inhibition of AP-1 expressed in HEK293 cells assessed as PMA-stimulated transcriptional activation at 10 uM treated 24 hrs before PMA challenge measured after 20 to 24 hrs by luciferase reporter gene assay | 37 | ALA1156197 | cell-based format | Scientific Literature | ||
3. | ALA1106184 | B | Inhibition of NF-kappaB expressed in HEK293 cells assessed as inhibition of TNF-alpha-stimulated transcriptional activation at 1 uM treated 24 hrs before TNFalpha challenge measured after 20 to 24 hrs by luciferase reporter gene assay | 37 | ALA1156197 | cell-based format | Scientific Literature | ||
4. | ALA1106185 | B | Inhibition of AP-1 expressed in HEK293 cells assessed as PMA-stimulated transcriptional activation at 1 uM treated 24 hrs before PMA challenge measured after 20 to 24 hrs by luciferase reporter gene assay | 37 | ALA1156197 | cell-based format | Scientific Literature | ||
5. | ALA1106186 | B | Inhibition of NF-kappaB expressed in HEK293 cells assessed as inhibition of TNF-alpha-stimulated transcriptional activation treated 24 hrs before TNFalpha challenge measured after 20 to 24 hrs by luciferase reporter gene assay | 7 | ALA1156197 | cell-based format | Scientific Literature | ||
6. | ALA1106187 | B | Inhibition of AP-1 expressed in HEK293 cells assessed as PMA-stimulated transcriptional activation treated 24 hrs before PMA challenge measured after 20 to 24 hrs by luciferase reporter gene assay | 7 | ALA1156197 | cell-based format | Scientific Literature | ||
7. | ALA1106188 | F | Antiinflammatory activity against carrageenan-induced paw edema in Sprague-Dawley rat assessed as reduction in paw volume at 50 mg/kg, po dosed 1 hr before carrageenan challenge measured after 3 hrs by plethysmometry | Rattus norvegicus | 8 | ALA1156197 | organism-based format | Scientific Literature | |
8. | ALA1106189 | F | Inhibition of LPS-stimulated NF-kappaB activation in transgenic FVB mouse assessed as decrease in NF-kappaB activity at 50 mg/kg, po QD for 3 days before LPS challenge measured after 3 hrs by bioluminescence based luciferase reporter gene assay relative to control | Mus musculus | 1 | ALA1156197 | organism-based format | Scientific Literature | |
9. | ALA1106190 | A | Cytotoxicity against TNF-alpha-stimulated HEK293 cells at 10 uM treated 24 hrs before TNFalpha challenge measured after 20 to 24 hrs | Homo sapiens | 37 | ALA1156197 | cell-based format | Scientific Literature | |
10. | ALA1106191 | F | Cytotoxicity against human LNCAP cells | Homo sapiens | 1 | ALA1156197 | cell-based format | Scientific Literature | |
11. | ALA1106192 | F | Cytotoxicity against human PC3 cells | Homo sapiens | 1 | ALA1156197 | cell-based format | Scientific Literature | |
12. | ALA1106193 | F | Cytotoxicity against human TCCSUP cells | Homo sapiens | 1 | ALA1156197 | cell-based format | Scientific Literature | |
13. | ALA3367176 | B | Inhibition of AP-1-mediated transcriptional activation in HEK293 cells by luciferase reporter gene assay | Homo sapiens | 6 | ALA3352097 | cell-based format | Scientific Literature | |
14. | ALA3367177 | B | Inhibition of NF-kappaB-mediated transcriptional activation in HEK293 cells by luciferase reporter gene assay | Homo sapiens | 6 | ALA3352097 | cell-based format | Scientific Literature |