# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1106238 | Functional | Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as inflection point for increase of EC20 of acetylcholine-induced calcium mobilization by FLIPR assay | Homo sapiens | 27 | ALA1156223 | cell-based format | Scientific Literature | |
2. | ALA1106240 | ADME | Plasma protein binding in rat by equilibrium dialysis method | Rattus norvegicus | 10 | ALA1156223 | cell-free format | Scientific Literature | |
3. | ALA1106241 | ADME | Plasma protein binding in human by equilibrium dialysis method | Homo sapiens | 10 | ALA1156223 | cell-free format | Scientific Literature | |
4. | ALA1106242 | ADME | Apparent permeability of the compound | 3 | ALA1156223 | assay format | Scientific Literature | ||
5. | ALA1106243 | ADME | Effect on human MDR1-mediated drug transport assessed as efflux ratio of permeability from basolateral to apical side to apical to basolateral side | Homo sapiens | 3 | ALA1156223 | single protein format | Scientific Literature | |
6. | ALA1106244 | ADME | Effect on rat MDR1a-mediated drug transport assessed as efflux ratio of permeability from basolateral to apical side to apical to basolateral side | Rattus norvegicus | 3 | ALA1156223 | single protein format | Scientific Literature | |
7. | ALA1106245 | ADME | Drug levell in Sprague-Dawley rat plasma at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1156223 | organism-based format | Scientific Literature | |
8. | ALA1106246 | ADME | Drug level in Sprague-Dawley rat brain at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1156223 | organism-based format | Scientific Literature | |
9. | ALA1106247 | ADME | Drug level in Sprague-Dawley rat CSF at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1156223 | organism-based format | Scientific Literature | |
10. | ALA1106248 | ADME | Ratio of drug levell in brain to plasma in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1156223 | organism-based format | Scientific Literature | |
11. | ALA1106249 | ADME | Ratio of drug levell in CSF to fraction unbound in plasma in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA1156223 | organism-based format | Scientific Literature |