# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1107364 | Functional | Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay | Homo sapiens | 16 | ALA1157078 | cell-based format | Scientific Literature | |
2. | ALA1107365 | Functional | Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay | Homo sapiens | 16 | ALA1157078 | cell-based format | Scientific Literature | |
3. | ALA1107366 | Functional | Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay | Homo sapiens | 16 | ALA1157078 | cell-based format | Scientific Literature | |
4. | ALA1107367 | Functional | Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay | Homo sapiens | 16 | ALA1157078 | cell-based format | Scientific Literature | |
5. | ALA1107368 | Functional | Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay | Homo sapiens | 16 | ALA1157078 | cell-based format | Scientific Literature | |
6. | ALA1107369 | ADME | Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay | Homo sapiens | 16 | ALA1157078 | cell-based format | Scientific Literature | |
7. | ALA1107370 | Functional | Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method | Homo sapiens | 15 | ALA1157078 | cell-based format | Scientific Literature | |
8. | ALA4612465 | Binding | Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay | Oryctolagus cuniculus | 7 | ALA4610111 | cell-based format | Scientific Literature | |
9. | ALA4612466 | Binding | Inhibition of SERCA1 in rat INS-1E cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Rattus norvegicus | 7 | ALA4610111 | cell-based format | Scientific Literature | |
10. | ALA4612467 | Binding | Binding affinity to cytosolic region of SERCA1 ATP binding site in NewZealand rabbit SR vesicles assessed as conformational changes by measuring decrease in fluorescence intensity at IC50 incubated for 1 hr by FITC probe labeling based analysis | Oryctolagus cuniculus | 7 | ALA4610111 | cell-based format | Scientific Literature | |
11. | ALA4612468 | Binding | Binding affinity to transmembrane region of SERCA1A ATP binding site in NewZealand rabbit SR vesicles assessed as conformational changes by measuring intrinsic Trp fluorescence at IC50 incubated for 30 mins by spectrofluorometric analysis | Oryctolagus cuniculus | 7 | ALA4610111 | cell-based format | Scientific Literature | |
12. | ALA4612470 | Binding | Inhibition of SERCA1 in glucose-stimulated rat INS-1E cells assessed as decline in insulin release preincubated for 24 hrs followed by glucose addition and measured after 30 mins by RIA | Rattus norvegicus | 7 | ALA4610111 | assay format | Scientific Literature | |
13. | ALA4612471 | Binding | Inhibition of SERCA1 in rat INS-1E cells assessed as induction of apoptosis by measuring decrease in living cells at IC50 for cell viability incubated for 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry | Rattus norvegicus | 7 | ALA4610111 | cell-based format | Scientific Literature | |
14. | ALA4612472 | Binding | Inhibition of SERCA1 in rat INS-1E cells assessed as induction of apoptosis by measuring increase in early apoptotic cells at IC50 for cell viability incubated for 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry | Rattus norvegicus | 7 | ALA4610111 | cell-based format | Scientific Literature | |
15. | ALA4612473 | Binding | Inhibition of SERCA1 in rat INS-1E cells assessed as induction of apoptosis by measuring increase in late apoptotic cells at IC50 for cell viability incubated for 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry | Rattus norvegicus | 7 | ALA4610111 | cell-based format | Scientific Literature | |
16. | ALA4612474 | Binding | Inhibition of SERCA1 in rat INS-1E cells assessed as insulin release preincubated for 24 hrs followed by incubation in glucose-free buffer and measured after 30 mins by RIA | Rattus norvegicus | 7 | ALA4610111 | cell-based format | Scientific Literature |