# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1120985 | Functional | Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor activation by luciferase reporter gene assay | 16 | ALA1157753 | cell-based format | Scientific Literature | ||
2. | ALA1120986 | Binding | Inhibition of L-type calcium channel in rat A10 cells assessed as inhibition of depolarization-induced increase in calcium flux after 48 hrs by FLIPR assay | Rattus norvegicus | 16 | ALA1157753 | cell-based format | Scientific Literature | |
3. | ALA1120987 | Binding | Inhibition of glucocorticoid receptor | 3 | ALA1157753 | single protein format | Scientific Literature | ||
4. | ALA1120988 | Binding | Inhibition of androgen receptor | 3 | ALA1157753 | single protein format | Scientific Literature | ||
5. | ALA1120989 | Binding | Inhibition of progesterone receptor | 3 | ALA1157753 | single protein format | Scientific Literature | ||
6. | ALA1120990 | Binding | Inhibition of estrogen receptor | 3 | ALA1157753 | single protein format | Scientific Literature | ||
7. | ALA1120991 | Binding | Selectivity ratio of IC50 for glucocorticoid receptor to IC50 for Gal4-fused mineralocorticoid receptor | 3 | ALA1157753 | assay format | Scientific Literature | ||
8. | ALA1120992 | Binding | Selectivity ratio of IC50 for androgen receptor to IC50 for Gal4-fused mineralocorticoid receptor | 3 | ALA1157753 | assay format | Scientific Literature | ||
9. | ALA1120993 | ADME | Clearance in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA1157753 | organism-based format | Scientific Literature | |
10. | ALA1120994 | ADME | Half life in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA1157753 | organism-based format | Scientific Literature | |
11. | ALA1120995 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA1157753 | organism-based format | Scientific Literature |