# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1113881 | F | Cytotoxicity against mouse Mel-Ab cells at 1 to 100 uM after 24 hrs by crystal violet assay | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
2. | ALA1113882 | F | Inhibition of melanin synthesis in mouse Mel-Ab cells assessed as reduction in melanin synthesis at 1 to 100 uM after 4 hrs by phase-contrast microscopy | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
3. | ALA1113883 | F | Inhibition of melanin synthesis in mouse Mel-Ab cells assessed as in melanin content after 4 hrs by ELISA | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
4. | ALA1113884 | B | Inhibition of mushroom tyrosinase by cell free assay system | Agaricus bisporus | 1 | ALA1158586 | single protein format | Scientific Literature | |
5. | ALA1116493 | B | Inhibition of tyrosinase activity in mouse Mel-Ab cells assessed as inhibition of melanogenesis at 1 to 100 uM after 4 hrs by ELISA | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
6. | ALA1116494 | B | Induction of ERK activity in 24 hrs serum starved mouse Mel-Ab cells at 50 uM by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
7. | ALA1116495 | B | Induction of Akt activity in 24 hrs serum starved mouse Mel-Ab cells at 50 uM by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
8. | ALA1116496 | B | Down regulation of MITF activity in 24 hrs serum starved mouse Mel-Ab cells at 50 uM measured after 60 to 360 mins by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
9. | ALA1116497 | F | Reduction of MITF level in 24 hrs serum starved mouse Mel-Ab cells at 50 uM measured after 24 to 72 mins by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-free format | Scientific Literature | |
10. | ALA1116498 | F | Reduction of tyrosinase protein level in 24 hrs serum starved mouse Mel-Ab cells at 50 uM measured after 24 to 72 mins by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-free format | Scientific Literature | |
11. | ALA1116499 | F | Inhibition of melanin synthesis in mouse Mel-Ab cells assessed as reduction in melanin synthesis at 50 uM after 4 hrs by phase-contrast microscopy in presence of PD-98059 ERK pathway inhibitor | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
12. | ALA1117384 | F | Reduction of MITF level in 24 hrs serum starved mouse Mel-Ab cells at 25 ug/ml measured after 3 hrs followed by MG132 proteasome inhibitor for 1 hr by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-free format | Scientific Literature | |
13. | ALA1117385 | F | Reduction of MITF level in 24 hrs serum starved mouse Mel-Ab cells at 25 ug/ml measured after 3 hrs followed by chloroquine lysosomal proteolysis inhibitor for 1 hr by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-free format | Scientific Literature | |
14. | ALA1117386 | F | Reduction of MITF level in 24 hrs serum starved mouse Mel-Ab cells at 25 ug/ml measured after 3 hrs followed by MG132/chloroquine for 1 hr by Western blot analysis | Mus musculus | 1 | ALA1158586 | cell-free format | Scientific Literature | |
15. | ALA1117387 | B | Induction of ERK activity in 24 hrs serum starved mouse Mel-Ab cells at 50 uM by Western blot analysis in presence of PD-98059 | Mus musculus | 1 | ALA1158586 | cell-based format | Scientific Literature | |
16. | ALA1117388 | F | Reduction of MITF level in 24 hrs serum starved mouse Mel-Ab cells at 50 uM measured after 24 to 72 mins by Western blot analysis in presence of PD-98059 | Mus musculus | 1 | ALA1158586 | cell-free format | Scientific Literature | |
17. | ALA1641169 | F | Inhibition of melanin production in mouse B16F10 cells at 100 uM after 2 days | Mus musculus | 33 | ALA1629471 | cell-based format | Scientific Literature | |
18. | ALA1641170 | A | Cytotoxicity against mouse B16F10 cells assessed as cell viability after 24 hrs by MTT assay | Mus musculus | 34 | ALA1629471 | cell-based format | Scientific Literature | |
19. | ALA3830033 | B | Inhibition of Wnt/beta-catenin pathway in human HEK293 cells at 20 uM after 15 hrs by TOPflash dual luciferase reporter gene assay | Homo sapiens | 45 | ALA3826880 | cell-based format | Scientific Literature |