Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by FLIPR assay
Antipsychotic activity in Wistar Hannover rat assessed as inhibition of ketamine-induced hyperlocomotion at 30 to 100 mg/kg, ip measured for first 30 mins
Antipsychotic activity in Wistar Hannover rat assessed as inhibition of ketamine-induced hyperlocomotion at 30 to 100 mg/kg, ip measured for second 30 mins
Agonist activity at human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by FLIPR assay relative to glutamate
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by FLIPR assay relative to glutamate
Agonist activity at human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by LIPR assay