# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1107471 | Functional | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins | 24 | ALA1158546 | cell-based format | Scientific Literature | ||
2. | ALA1107473 | Functional | Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge | 5 | ALA1158546 | cell-based format | Scientific Literature | ||
3. | ALA1107474 | Functional | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge | 5 | ALA1158546 | cell-based format | Scientific Literature | ||
4. | ALA1107476 | Physicochemical | Lipophilicity, log D of compound at pH 7.4 | 6 | ALA1158546 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA1107477 | ADME | Solubility of compound in small intestinal contents in the fed state at pH 5 | 6 | ALA1158546 | assay format | Scientific Literature | ||
6. | ALA1107478 | ADME | Solubility of compound in small intestinal contents in the fasted state at pH 6.5 | 6 | ALA1158546 | assay format | Scientific Literature | ||
7. | ALA1107479 | ADME | Clearance in rat hepatocytes after 3 hrs | Rattus norvegicus | 6 | ALA1158546 | cell-based format | Scientific Literature | |
8. | ALA1107480 | Binding | Inhibition of human ERG expressed in CHO cells assessed as reduction of current amplitude | Homo sapiens | 6 | ALA1158546 | cell-based format | Scientific Literature | |
9. | ALA1107481 | Binding | Inhibition of human ERG expressed in CHO cells at 3 uM assessed as reduction of current amplitude | Homo sapiens | 6 | ALA1158546 | cell-based format | Scientific Literature | |
10. | ALA1107482 | ADME | Inhibition of CYP1A2 by fluorescence method | 6 | ALA1158546 | single protein format | Scientific Literature | ||
11. | ALA1107483 | ADME | Inhibition of CYP2D6 fluorescence method | 6 | ALA1158546 | single protein format | Scientific Literature | ||
12. | ALA1107484 | ADME | Inhibition of CYP2C19 fluorescence method | 6 | ALA1158546 | single protein format | Scientific Literature | ||
13. | ALA1107485 | ADME | Inhibition of CYP3A4 fluorescence method | 6 | ALA1158546 | single protein format | Scientific Literature | ||
14. | ALA1107486 | ADME | Inhibition of CYP2C9 fluorescence method | 6 | ALA1158546 | single protein format | Scientific Literature | ||
15. | ALA1107487 | ADME | Inhibition of CYP2C9 by LC/MS method | 6 | ALA1158546 | single protein format | Scientific Literature | ||
16. | ALA1107488 | ADME | Half life in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 4 | ALA1158546 | organism-based format | Scientific Literature | |
17. | ALA1107489 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 4 | ALA1158546 | organism-based format | Scientific Literature | |
18. | ALA1108255 | ADME | Tmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 4 | ALA1158546 | organism-based format | Scientific Literature | |
19. | ALA1108256 | ADME | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 4 | ALA1158546 | organism-based format | Scientific Literature | |
20. | ALA1115514 | ADME | Half life in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 3 | ALA1158546 | organism-based format | Scientific Literature |