| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1113939 | B | Inhibition of Plasmodium falciparum plasmepsin-2 expressed in Escherichia coli BL21 (DE3) at 1 uM after 30 min by FRET assay | Plasmodium falciparum | 5 | ALA1157812 | assay format | Scientific Literature | |
| 2. | ALA1113940 | B | Competitive inhibition of Plasmodium falciparum plasmepsin-2 expressed in Escherichia coli BL21 (DE3) after 30 min by FRET assay | Plasmodium falciparum | 4 | ALA1157812 | assay format | Scientific Literature | |
| 3. | ALA1114763 | B | Inhibition of Plasmodium falciparum plasmepsin-2 expressed in Escherichia coli BL21 (DE3) at 1 uM after 1 to 2 hrs | Plasmodium falciparum | 5 | ALA1157812 | assay format | Scientific Literature | |
| 4. | ALA1114764 | B | Inhibition of Plasmodium falciparum plasmepsin-2 expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 1 uM measured after overnight dialysis by spun column chromatography | Plasmodium falciparum | 3 | ALA1157812 | assay format | Scientific Literature | |
| 5. | ALA1114765 | B | Irreversible inhibition of Plasmodium falciparum plasmepsin-2 expressed in Escherichia coli BL21 (DE3) at 1 uM measured after overnight dialysis by spun column chromatography | Plasmodium falciparum | 4 | ALA1157812 | assay format | Scientific Literature | |
| 6. | ALA1114767 | B | Inhibition of human cathepsin D after 30 mins by FRET assay | Homo sapiens | 4 | ALA1157812 | single protein format | Scientific Literature | |
| 7. | ALA1114768 | B | Selectivity ratio of IC50 for human cathepsin D to IC50 for Plasmodium falciparum plasmepsin-2 expressed in Escherichia coli BL21 (DE3) | 3 | ALA1157812 | assay format | Scientific Literature | ||
| 8. | ALA1114769 | A | Cytotoxicity against CHO cells at 10 uM after 24 hrs by MTS assay | Cricetulus griseus | 4 | ALA1157812 | cell-based format | Scientific Literature | |
| 9. | ALA1114772 | F | Antiplasmodial activity against Plasmodium falciparum 3D7 trophozoites infected in human erythrocytes assessed as [3H]hypoxanthine incorporation into nucleic acid after 30 hrs by beta-scintillation counting | Plasmodium falciparum | 6 | ALA1157812 | organism-based format | Scientific Literature | |
| 10. | ALA4357653 | B | Inhibition of recombinant Plasmodium falciparum Plasmepsin 2 | Plasmodium falciparum | 28 | ALA4354841 | single protein format | Scientific Literature | |
| 11. | ALA4357654 | B | Inhibition of Plasmodium falciparum recombinant Plasmepsin 2 assessed as enzyme activity relative to control | Plasmodium falciparum | 2 | ALA4354841 | single protein format | Scientific Literature | |
| 12. | ALA4357655 | B | Selectivity index, ratio of IC50 for human cathepsin D to IC50 for inhibition of recombinant Plasmodium falciparum Plasmepsin 2 | 3 | ALA4354841 | assay format | Scientific Literature | ||
| 13. | ALA4357656 | F | Antimalarial activity against Plasmodium falciparum 3D7 | Plasmodium falciparum | 3 | ALA4354841 | organism-based format | Scientific Literature |
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