# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1118750 | Binding | Inhibition of pig pancreas group 1B sPLA2 assessed as inhibition of POPG cleavage at 10 uM after 30 mins by HPLC analysis | Sus scrofa | 2 | ALA1155440 | single protein format | Scientific Literature | |
2. | ALA1805785 | Binding | Inhibition of pig pancreas group 1B sPLA2 assessed as release of oleic acid using 2-oleoyl-1-palmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (ammonium salt) as substrate at 10 uM by UV-reverse phase HPLC analysis | Sus scrofa | 2 | ALA1799943 | single protein format | Scientific Literature | |
3. | ALA3301372 | ADME | ASTRAZENECA: Intrinsic clearance measured in human hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736. | Homo sapiens | 408 | ALA3301361 | cell-based format | AstraZeneca Deposited Data | |
4. | ALA3807561 | Binding | Inhibition of secretory phospholipase A2 in rat renal mesangial cells assessed as suppression of IL-1beta/forskolin stimulated PGE2 formation preincubated for 20 mins prior to IL-1beta/forskolin challenge at 1 to 10 uM measured after 24 hrs by PGE2-specific ELISA | Rattus norvegicus | 8 | ALA3804823 | cell-based format | Scientific Literature | |
5. | ALA4134898 | Binding | Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux at 5 uM measured within 60 mins by whole cell patch clamp electrophysiology method | Homo sapiens | 1 | ALA4130479 | cell-based format | Scientific Literature | |
6. | ALA4134902 | ADME | Cytotoxicity against HEK293 cells assessed as cell death at 25 to 50 uM measured for 1 hr | Homo sapiens | 1 | ALA4130479 | cell-based format | Scientific Literature |