# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1120632 | Binding | Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
2. | ALA1120633 | Binding | Displacement of [3H]PGD2 from human Prostanoid DP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
3. | ALA1120634 | Binding | Displacement of [3H]PGE2 from human prostanoid EP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
4. | ALA1120635 | Binding | Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
5. | ALA1120636 | Binding | Displacement of [3H]PGE2 from human prostanoid EP3 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
6. | ALA1117650 | Binding | Displacement of [3H]PGD2 from human Prostanoid DP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
7. | ALA1117651 | Binding | Displacement of [3H]iloprost from human prostanoid IP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
8. | ALA1117652 | Binding | Displacement of [3H]SQ-29548 from human prostanoid TP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
9. | ALA1117653 | Binding | Displacement of [3H]PGF2alpha from human prostanoid FP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
10. | ALA1117654 | Functional | Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay | Homo sapiens | 12 | ALA1155539 | cell-based format | Scientific Literature | |
11. | ALA1117769 | Binding | Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting in presence of 10% human serum | Homo sapiens | 1 | ALA1155539 | cell-based format | Scientific Literature | |
12. | ALA1117770 | Functional | Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serum | Homo sapiens | 1 | ALA1155539 | cell-based format | Scientific Literature | |
13. | ALA1117771 | Functional | Antagonist activity at prostanoid EP4 receptor in human whole blood assessed as inhibition of TNF-alpha-induced IP-10 release in presence EP4 agonist L-000902688 | Homo sapiens | 1 | ALA1155539 | tissue-based format | Scientific Literature | |
14. | ALA1117772 | ADME | Metabolic stability in human hepatocytes | Homo sapiens | 1 | ALA1155539 | cell-based format | Scientific Literature | |
15. | ALA1117773 | ADME | Metabolic stability in dog hepatocytes | Canis lupus familiaris | 1 | ALA1155539 | cell-based format | Scientific Literature | |
16. | ALA1117774 | ADME | Metabolic stability in rat hepatocytes | Rattus norvegicus | 1 | ALA1155539 | cell-based format | Scientific Literature | |
17. | ALA1117775 | ADME | Plasma clearance in Sprague-Dawley rat at 5 mg/kg, iv and 20 mg/kg, po | Rattus norvegicus | 1 | ALA1155539 | organism-based format | Scientific Literature | |
18. | ALA1117776 | ADME | Plasma clearance in Beagle dog at 5 mg/kg, iv and 20 mg/kg, po | Canis lupus familiaris | 1 | ALA1155539 | organism-based format | Scientific Literature | |
19. | ALA1117777 | ADME | Volume of distribution in Sprague-Dawley rat at 5 mg/kg, iv and 20 mg/kg, po | Rattus norvegicus | 1 | ALA1155539 | organism-based format | Scientific Literature | |
20. | ALA1117778 | ADME | Volume of distribution in Beagle dog at 5 mg/kg, iv and 20 mg/kg, po | Canis lupus familiaris | 1 | ALA1155539 | organism-based format | Scientific Literature |