# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1169053 | B | Inhibition of PTP1B assessed as p-nitrophenolate ion production at 100 uM pretreated for 10 mins measured after 30 mins | 32 | single protein format | Scientific Literature | |||
2. | ALA1169054 | B | Inhibition of DPP4 at 100 uM after 15 mins by spectrofluorimeter | 33 | single protein format | Scientific Literature | |||
3. | ALA1169055 | B | Inhibition of alpha-glucosidase at 100 uM after 3 mins | 32 | assay format | Scientific Literature | |||
4. | ALA1169056 | B | Inhibition of glycogen phosphorylase assessed as inositol phosphate release at 100 uM after 30 mins | 32 | assay format | Scientific Literature | |||
5. | ALA1169057 | B | Inhibition of glucose-6-phosphatase assessed as inositol phosphate release at 100 uM after 30 mins | 32 | single protein format | Scientific Literature | |||
6. | ALA1169063 | F | Antihyperglycemic activity in Sprague-Dawley albino rat streptozotocin-induced beta-cell damaged diabetic model assessed as decrease of blood glucose level at 100 mg/kg, po administered 30 mins before glucose challenge measured after 24 hrs by glucometer | Rattus norvegicus | 33 | organism-based format | Scientific Literature | ||
7. | ALA1169064 | F | Antihyperglycemic activity in Sprague-Dawley albino rat streptozotocin-induced beta-cell damaged diabetic model assessed as decrease of blood glucose level at 100 mg/kg, po administered 30 mins before glucose challenge measured after 5 hrs by glucometer | Rattus norvegicus | 33 | organism-based format | Scientific Literature | ||
8. | ALA1169065 | F | Antihyperglycemic activity in Charles Foster-Wistar albino rat sucrose loaded model assessed as decrease of blood glucose level at 100 mg/kg, po administered 30 mins before glucose challenge measured up to 120 mins by glucometer | Rattus norvegicus | 34 | organism-based format | Scientific Literature | ||
9. | ALA1169066 | F | Antidyslipidemic activity in Charles Foster rat assessed as reduction of Triton WR-1339-induced increase of blood total cholesterol level at 100 mg/kg, po after 18 hrs | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
10. | ALA1169067 | F | Antidyslipidemic activity in Charles Foster rat assessed as reduction of Triton WR-1339-induced increase of blood phospholipid level at 100 mg/kg, po after 18 hrs | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
11. | ALA1169068 | F | Antidyslipidemic activity in Charles Foster rat assessed as reduction of Triton WR-1339-induced increase of blood triglyceride level at 100 mg/kg, po after 18 hrs | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
12. | ALA3270056 | B | Inhibition of human Cav1.3 channel in human SH-SY5Y cells assessed as 70 mM K+ induced calcium elevation compound treated 15 mins before stimulus by Fluo-4/AM assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
13. | ALA3270057 | B | Inhibition of rat Cav1.2 channel in rat mesenteric artery assessed as relaxation of 70 mM K+ induced contraction | Rattus norvegicus | 24 | tissue-based format | Scientific Literature | ||
14. | ALA3270058 | B | Selectivity ratio of IC50 for human Cav1.3 channel to IC50 for rat Cav1.2 channel | 4 | assay format | Scientific Literature | |||
15. | ALA3270059 | F | Neuroprotective activity against K+ induced Ca2+ overload in human SH-SY5Y cells assessed as survival at 5 uM after 24 hrs by MTT assay (Rvb = 52.1 +/- 3.5%) | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
16. | ALA3265719 | F | Neuroprotective activity against K+ induced Ca2+ overload in human SH-SY5Y cells assessed as protection at 5 uM after 24 hrs by MTT assay relative to control | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
17. | ALA3265720 | F | Neuroprotective activity against rotenone-oligomycin A-induced oxidative stress in human SH-SY5Y cells assessed as survival at 5 uM co-incubated rot/oligo for 24 hrs by MTT assay (Rvb =65.6 +/- 1.3%) | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
18. | ALA3265721 | F | Neuroprotective activity against rotenone-oligomycin A-induced oxidative stress in human SH-SY5Y cells assessed as protection at 5 uM co-incubated rot/oligo for 24 hrs by MTT assay relative to control | Homo sapiens | 22 | cell-based format | Scientific Literature |