# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1177271 | B | Displacement of 5(6)-FAM-mannoside from Escherichia coli FimH by fluorescence polarization assay | Escherichia coli | 20 | ALA1177710 | assay format | Scientific Literature | |
2. | ALA1177272 | B | Inhibition of Escherichia coli FimH-mediated hemagglutinination of guinea pig red blood cells assessed as drug level required for > 90% inhibition of hemagglutinination | Escherichia coli | 71 | ALA1177710 | assay format | Scientific Literature | |
3. | ALA1177276 | B | Binding affinity to Escherichia coli FimH by surface plasmon resonance assay | Escherichia coli | 3 | ALA1177710 | assay format | Scientific Literature | |
4. | ALA1805065 | B | Competitive inhibition of His-tagged FimH carbohydrate recognizing domain expressed in Escherichia coli HM125 using ABTS-substrate after 3 hrs by calorimetric assay | Escherichia coli | 18 | ALA1799951 | assay format | Scientific Literature | |
5. | ALA1805066 | B | Ratio IC50 for compound to IC50 for n-heptyl R-D-mannopyranoside for His-tagged FimH expressed in Escherichia coli HM125 | Escherichia coli | 18 | ALA1799951 | assay format | Scientific Literature | |
6. | ALA1805067 | F | Antagonist activity at Escherichia coli UT189 FimH in guinea pig red blood cells assessed as disaggregation of bacteria after 600 secs by aggregometry assay | Escherichia coli | 18 | ALA1799951 | cell-based format | Scientific Literature | |
7. | ALA1805068 | B | Binding affinity to MBP at 1 mM | 3 | ALA1799951 | single protein format | Scientific Literature | ||
8. | ALA1805238 | B | Binding affinity to Fc-IgG-tagged DC-SIGN carbohydrate recognizing domain at 1 mM | 3 | ALA1799951 | single protein format | Scientific Literature | ||
9. | ALA1805240 | P | Lipophilicity, log D at pH 7.4 by miniatured shake flask method | 18 | ALA1799951 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA1805241 | A | Permeability coefficient, log Pe of the compound by PAMPA method | 18 | ALA1799951 | assay format | Scientific Literature | ||
11. | ALA1805242 | A | Permeability of the compound assessed as membrane retention by PAMPA method | 15 | ALA1799951 | assay format | Scientific Literature | ||
12. | ALA1805243 | A | Apparent permeability across human Caco2 cells after 120 mins by HPLC analysis | Homo sapiens | 18 | ALA1799951 | cell-based format | Scientific Literature | |
13. | ALA1805244 | P | Thermodynamic solubility of the compound at pH 6.5 after 24 hrs by LC-MS analysis | 18 | ALA1799951 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA1805245 | P | Stability of the compound in simulated gastrointestinal fluid assessed as compound remaining after 2 hrs by LC-MS analysis | 3 | ALA1799951 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA1805246 | P | Stability of the compound in simulated intestinal fluid assessed as compound remaining after 2 hrs by LC-MS analysis | 3 | ALA1799951 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA1805250 | A | Plasma protein binding in human by miniatured equilibrium dialysis method | Homo sapiens | 18 | ALA1799951 | cell-free format | Scientific Literature | |
17. | ALA1805251 | A | Cmax in plasma of urinary tract infection C3H/HeN mouse model at 50 mg/kg, iv administered as single dose measured after 6 hrs by LC-MS analysis | Mus musculus | 3 | ALA1799951 | organism-based format | Scientific Literature | |
18. | ALA1805322 | A | Cmax in urine of urinary tract infection C3H/HeN mouse model at 50 mg/kg, iv administered as single dose measured after 6 hrs by LC-MS analysis | Mus musculus | 3 | ALA1799951 | organism-based format | Scientific Literature | |
19. | ALA1805323 | A | AUC (0 to 24 hrs) in plasma of urinary tract infection C3H/HeN mouse model at 50 mg/kg, iv administered as single dose measured after 6 hrs by LC-MS analysis | Mus musculus | 3 | ALA1799951 | organism-based format | Scientific Literature | |
20. | ALA1805324 | A | AUC (0 to 24 hrs) in urine of urinary tract infection C3H/HeN mouse model at 50 mg/kg, iv administered as single dose measured after 6 hrs by LC-MS analysis | Mus musculus | 3 | ALA1799951 | organism-based format | Scientific Literature |