# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2067377 | B | Ratio of compound IC50 to n-heptyl alpha-D-mannopyranoside IC50 for Escherichia coli His6-tagged FimH carbohydrate recognition domain | Escherichia coli | 24 | assay format | Scientific Literature | ||
2. | ALA2067378 | F | Antagonist activity at Escherichia coli UTI89 FimH assessed as inhibition of aggregation with guinea pig erythrocytes after 1400 secs by aggregometry | Escherichia coli | 24 | organism-based format | Scientific Literature | ||
3. | ALA2067379 | B | Ratio of compound IC50 to n-heptyl alpha-D-mannopyranoside IC50 for Escherichia coli UTI89 FimH-mediated guinea pig erythrocyte aggregation | Escherichia coli | 18 | organism-based format | Scientific Literature | ||
4. | ALA2067399 | B | Displacement of [TMPAA]-biotin from Escherichia coli His6-tagged FimH carbohydrate recognition domain expressed in Escherichia coli HM125 after 3 hrs by colorimetric analysis | Escherichia coli | 24 | assay format | Scientific Literature | ||
5. | ALA1805065 | B | Competitive inhibition of His-tagged FimH carbohydrate recognizing domain expressed in Escherichia coli HM125 using ABTS-substrate after 3 hrs by calorimetric assay | Escherichia coli | 18 | assay format | Scientific Literature | ||
6. | ALA1805066 | B | Ratio IC50 for compound to IC50 for n-heptyl R-D-mannopyranoside for His-tagged FimH expressed in Escherichia coli HM125 | Escherichia coli | 18 | assay format | Scientific Literature | ||
7. | ALA1805067 | F | Antagonist activity at Escherichia coli UT189 FimH in guinea pig red blood cells assessed as disaggregation of bacteria after 600 secs by aggregometry assay | Escherichia coli | 18 | cell-based format | Scientific Literature | ||
8. | ALA1805068 | B | Binding affinity to MBP at 1 mM | 3 | single protein format | Scientific Literature | |||
9. | ALA1805238 | B | Binding affinity to Fc-IgG-tagged DC-SIGN carbohydrate recognizing domain at 1 mM | 3 | single protein format | Scientific Literature | |||
10. | ALA1805240 | P | Lipophilicity, log D at pH 7.4 by miniatured shake flask method | 18 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA1805241 | A | Permeability coefficient, log Pe of the compound by PAMPA method | 18 | assay format | Scientific Literature | |||
12. | ALA1805242 | A | Permeability of the compound assessed as membrane retention by PAMPA method | 15 | assay format | Scientific Literature | |||
13. | ALA1805243 | A | Apparent permeability across human Caco2 cells after 120 mins by HPLC analysis | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
14. | ALA1805244 | P | Thermodynamic solubility of the compound at pH 6.5 after 24 hrs by LC-MS analysis | 18 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA1805245 | P | Stability of the compound in simulated gastrointestinal fluid assessed as compound remaining after 2 hrs by LC-MS analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA1805246 | P | Stability of the compound in simulated intestinal fluid assessed as compound remaining after 2 hrs by LC-MS analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
17. | ALA1805250 | A | Plasma protein binding in human by miniatured equilibrium dialysis method | Homo sapiens | 18 | cell-free format | Scientific Literature | ||
18. | ALA1805251 | A | Cmax in plasma of urinary tract infection C3H/HeN mouse model at 50 mg/kg, iv administered as single dose measured after 6 hrs by LC-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
19. | ALA1805322 | A | Cmax in urine of urinary tract infection C3H/HeN mouse model at 50 mg/kg, iv administered as single dose measured after 6 hrs by LC-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
20. | ALA1805323 | A | AUC (0 to 24 hrs) in plasma of urinary tract infection C3H/HeN mouse model at 50 mg/kg, iv administered as single dose measured after 6 hrs by LC-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature |